Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valbenazine
Drug ID BADD_D02491
Description Valbenazine (development name NBI-98854) has been used in trials studying the treatment and basic science of Tourette Syndrome and Tardive Dyskinesia. In April, 2017, valbenazine was approved by the FDA (as Ingrezza) as the first and only approved treatment for adults with Tardive Dyskinesia (TD).
Indications and Usage For the treatment of tardive dyskinesia in adults [FDA Label].
Marketing Status Not Available
ATC Code N07XX13
DrugBank ID DB11915
KEGG ID D10675
MeSH ID C000603978
PubChem ID 24795069
TTD Drug ID D63WMQ
NDC Product Code 70370-1080; 47049-008; 70370-1060; 66406-0314; 47049-021; 70370-2040; 66406-0274; 70370-2048; 47049-009
Synonyms valbenazine | (2R,3R,11BR)-9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydro-2H- benzo(a)quinolizin-2-yl l-valinate | NBI-98854 | Ingrezza | valine 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo(a)quinolizin-2-yl ester
Chemical Information
Molecular Formula C24H38N2O4
CAS Registry Number 1025504-45-3
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1OC(=O)C(C(C)C)N)OC)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.018300%Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abnormal dreams19.02.03.001; 17.15.02.0010.006536%Not Available
Aggression19.05.01.0010.007843%Not Available
Agitation19.06.02.001; 17.02.05.0120.035293%
Akathisia19.06.02.006; 17.01.02.0020.037908%
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anger19.04.02.0010.006536%Not Available
Angioedema23.04.01.001; 10.01.05.009--Not Available
Ankle fracture12.04.01.005; 15.08.03.0050.002614%
Anxiety19.06.02.0020.053594%
Apathy19.04.04.0020.006536%Not Available
Aphasia19.21.01.001; 17.02.03.0010.003921%
Arthralgia15.01.02.001--
Aspiration22.02.07.0070.000682%
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Blister12.01.06.002; 23.03.01.001--Not Available
Blood glucose decreased13.02.02.0010.002614%Not Available
Blood pressure decreased13.14.03.002--Not Available
Blood pressure increased13.14.03.005--Not Available
Blood prolactin increased13.10.03.0020.002614%Not Available
Blunted affect19.04.01.0030.002614%Not Available
Bone pain15.02.01.001--
Bradykinesia17.01.02.0040.010457%Not Available
Bruxism19.11.03.001; 07.01.06.0080.002614%Not Available
Cardiac arrest02.03.04.001--
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