Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dexmethylphenidate
Drug ID BADD_D02457
Description Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002[A177181]. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant[A177193]. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer side effects than the l-isomer or the racemic mixture[A177181].
Indications and Usage Dexmethylphenidate is used as a treatment for ADHD, ideally in conjunction with psychological, educational, behavioral or other forms of treatment.
Marketing Status Not Available
ATC Code N06BA11
DrugBank ID DB06701
KEGG ID D07806
MeSH ID D064699
PubChem ID 154101
TTD Drug ID D02QCD
NDC Product Code Not Available
Synonyms Dexmethylphenidate Hydrochloride | Hydrochloride, Dexmethylphenidate | Focalin XR | XR, Focalin | Dexmethylphenidate | Focalin
Chemical Information
Molecular Formula C14H19NO2
CAS Registry Number 40431-64-9
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Seizure17.12.03.0010.000800%
Sinusitis22.07.03.007; 11.01.13.0050.000800%
Sleep disorder19.02.04.0010.000800%Not Available
Somnolence19.02.05.003; 17.02.04.0060.001200%
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.0030.000800%Not Available
Suicidal ideation19.12.01.0030.001600%
Tachycardia02.03.02.0070.001200%Not Available
Thinking abnormal19.10.03.001; 17.02.05.0230.001200%Not Available
Tic19.11.04.001; 17.02.05.0240.003201%Not Available
Tremor17.01.06.0020.002001%
Ventricular fibrillation02.03.04.0080.000800%
Vision blurred17.17.01.010; 06.02.06.0070.001200%
Visual impairment06.02.06.0080.001600%Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.0050.000800%
Weight increased13.15.01.0060.001600%
Energy increased08.01.03.0170.002001%Not Available
Performance status decreased08.01.03.0420.002401%Not Available
Emotional distress19.04.02.0080.000800%Not Available
Eye movement disorder17.02.05.025; 06.05.02.0080.000800%Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.008403%
Drug intolerance08.06.01.0130.001200%Not Available
Unevaluable event08.01.03.0510.000800%Not Available
Autism spectrum disorder19.22.02.0020.001200%Not Available
Body height increased13.15.01.0360.000800%Not Available
Amphetamines positive13.17.02.0090.001600%Not Available
The 3th Page    First    Pre   3    Total 3 Pages