Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Dexmethylphenidate
Drug ID BADD_D02457
Description Dexmethylphenidate is the dextrorotary form of methylphenidate introduced in 2002[A177181]. It is a norepinephrine-dopamine reuptake inhibitor (NDRI) and thus a psychostimulant[A177193]. It is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD)[Label,A177181]. The d-isomer is thought to have greater effect with fewer side effects than the l-isomer or the racemic mixture[A177181].
Indications and Usage Dexmethylphenidate is used as a treatment for ADHD, ideally in conjunction with psychological, educational, behavioral or other forms of treatment.
Marketing Status Not Available
ATC Code N06BA11
DrugBank ID DB06701
KEGG ID D07806
MeSH ID D064699
PubChem ID 154101
TTD Drug ID D02QCD
NDC Product Code Not Available
Synonyms Dexmethylphenidate Hydrochloride | Hydrochloride, Dexmethylphenidate | Focalin XR | XR, Focalin | Dexmethylphenidate | Focalin
Chemical Information
Molecular Formula C14H19NO2
CAS Registry Number 40431-64-9
SMILES COC(=O)C(C1CCCCN1)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Erection increased21.03.01.004; 19.08.04.0020.000800%Not Available
Euphoric mood19.04.02.0060.000800%
Fatigue08.01.01.002--
Feeling abnormal08.01.09.0140.002401%Not Available
Feeling jittery08.01.09.0160.001600%Not Available
Formication19.10.02.010; 17.02.06.0180.000800%Not Available
Hallucination19.10.02.0020.000800%
Hallucinations, mixed19.10.02.0070.000800%Not Available
Headache17.14.01.0010.005602%
Heart rate increased13.14.04.0020.002401%Not Available
Hyperhidrosis23.02.03.004; 08.01.03.0280.000800%
Hypersensitivity10.01.03.0030.001200%
Insomnia19.02.01.002; 17.15.03.0020.002001%
Irritability19.04.02.013; 08.01.03.0110.002001%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.0080.001200%
Malaise08.01.01.0030.003601%
Mood altered19.04.02.0070.002001%Not Available
Mood swings19.04.03.0010.001600%Not Available
Movement disorder17.01.02.0100.000800%Not Available
Muscle twitching15.05.03.0050.000800%Not Available
Nasopharyngitis22.07.03.002; 11.01.13.0020.000800%Not Available
Nausea07.01.07.0010.003201%
Pain08.01.08.004--
Palpitations02.01.02.0030.003601%
Paranoia19.05.01.0050.001600%Not Available
Peripheral coldness08.01.09.010; 24.04.03.0060.000800%Not Available
Pollakiuria20.02.02.0070.000800%
Psychomotor hyperactivity19.11.02.003; 17.01.02.0110.003201%Not Available
Rash23.03.13.0010.002001%Not Available
Restlessness19.11.02.002; 17.02.05.0210.001600%
The 2th Page    First    Pre   2 3    Next   Last    Total 3 Pages