Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vilazodone
Drug ID BADD_D02456
Description Vilazodone is a novel compound with combined high affinity and selectivity for the 5-hydroxytryptamine (5-HT) transporter and 5-HT(1A) receptors[Label,A177622]. Vilazodone may also be associated with less sexual dysfunction and weight gain[A6947]. Vilazodone was given FDA approval on January 21, 2011[L6046,A177622].
Indications and Usage Vilazodone is approved for treatment of acute episodes of major depression. Labeling of vilazodone describes an increased risk of suicidal thoughts in children, adolescents and young adults. The use of vilazodone in pediatrics is not indicated. Its use with monoamine oxidase inhibitors (MAOI) is contraindicated due to increased risk of serotonin syndome. Once the MAOI is discontinued, a 14-day washout period must pass before starting vilazodone.
Marketing Status Not Available
ATC Code N06AX24
DrugBank ID DB06684
KEGG ID D09698
MeSH ID D000069503
PubChem ID 6918314
TTD Drug ID D0X6BV
NDC Product Code Not Available
Synonyms Vilazodone Hydrochloride | Hydrochloride, Vilazodone | 2-benzofurancarboxamide, 5-(4-(4-(5-cyano-1H-indol-3-yl)butyl)-1-piperazinyl)-, hydrochloride (1:1) | Vilazodone HCl | HCl, Vilazodone | Viibryd | EMD 68843 | 68843, EMD | EMB-68843 | EMB 68843 | EMB68843 | Vilazodone | 5-(4-(4-(5-cyano-3-indolyl)butyl)-1-piperazinyl)benzofuran-2-carboxamide
Chemical Information
Molecular Formula C26H27N5O2
CAS Registry Number 163521-12-8
SMILES C1CN(CCN1CCCCC2=CNC3=C2C=C(C=C3)C#N)C4=CC5=C(C=C4)OC(=C5)C(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Night sweats23.02.03.006; 08.01.03.0310.001485%Not Available
Nightmare19.02.03.0030.014848%Not Available
Oedema14.05.06.010; 08.01.07.0060.002227%Not Available
Oedema peripheral08.01.07.007; 02.05.04.007; 14.05.06.011--
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Palpitations02.01.02.0030.007424%
Pancreatitis07.18.01.0010.002227%
Panic attack19.06.04.0010.001485%Not Available
Paraesthesia17.02.06.0050.033408%
Paranoia19.05.01.0050.003712%Not Available
Platelet count decreased13.01.04.001--
Presyncope24.06.02.010; 17.02.05.009; 02.01.02.0070.001485%
Pruritus23.03.12.0010.011136%
Psychomotor hyperactivity17.01.02.011; 19.11.02.0030.001485%Not Available
Rash23.03.13.001--Not Available
Rash pruritic23.03.12.0020.001485%Not Available
Rectal haemorrhage24.07.02.018; 07.12.03.0010.001485%
Renal failure20.01.03.005--Not Available
Restlessness19.11.02.002; 17.02.05.0210.002227%
Sedation17.02.04.0050.002970%Not Available
Seizure17.12.03.0010.013363%
Sensory disturbance17.02.07.0060.001485%Not Available
Serotonin syndrome17.05.02.004; 15.05.04.016; 12.03.01.0410.013363%Not Available
Sexual dysfunction21.03.02.003; 19.08.05.0020.009651%Not Available
Shock24.06.02.0020.001485%Not Available
Sleep disorder19.02.04.0010.002227%Not Available
Sleep paralysis19.02.02.004; 17.15.02.0050.006682%Not Available
Sleep terror19.02.03.008; 17.15.02.0060.005197%Not Available
Somnolence19.02.05.003; 17.02.04.0060.007424%
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