Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Lorcaserin
Drug ID BADD_D02448
Description Lorcaserin (previously APD-356), a highly selective 5HT2C receptor agonist, is used for the treatment of obesity. It has been shown to reduce body weight and food intake in animal models of obesity, and it is thought that targeting the 5HT2C receptor may alter body weight by regulating satiety. Lorcaserin is marketed as a salt form called Belviq, which is lorcaserin hydrochloride.
Indications and Usage For the treatment of obesity, as an adjunct to a reduced-calorie diet and increased physical activity.
Marketing Status Not Available
ATC Code A08AA11
DrugBank ID DB04871
KEGG ID D06613
MeSH ID C506658
PubChem ID 11658860
TTD Drug ID D01JMC
NDC Product Code Not Available
Synonyms lorcaserin | (1R)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine | Belviq | AR-10A | 8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-benzazepine | APD 356 | APD356 | APD-356
Chemical Information
Molecular Formula C11H14ClN
CAS Registry Number 616202-92-7
SMILES CC1CNCCC2=C1C=C(C=C2)Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Disturbance in attention19.21.02.002; 17.03.03.0010.001135%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.007663%
Dizziness postural17.02.05.004; 02.01.02.005; 24.06.02.0080.000426%Not Available
Dry mouth07.06.01.0020.000851%
Dyspepsia07.01.02.0010.000284%
Dyspnoea22.02.01.004; 02.01.03.002--
Emotional disorder19.04.02.0050.000284%Not Available
Euphoric mood19.04.02.0060.000426%
Fatigue08.01.01.0020.010502%
Feeling abnormal08.01.09.0140.003406%Not Available
Feeling cold08.01.09.0080.000284%Not Available
Feeling drunk08.01.09.0150.000426%Not Available
Feeling hot08.01.09.0090.000284%Not Available
Feeling jittery08.01.09.0160.001277%Not Available
Formication19.10.02.010; 17.02.06.0180.000568%Not Available
Galactorrhoea21.05.02.002; 05.03.04.0020.000426%Not Available
Glossodynia07.14.02.0010.000284%Not Available
Hallucination19.10.02.0020.000710%
Headache17.14.01.0010.013198%
Heart rate decreased13.14.04.0010.000284%Not Available
Heart rate increased13.14.04.0020.000568%Not Available
Hunger14.03.02.012; 08.01.09.0030.001135%Not Available
Hypoaesthesia17.02.06.0230.000710%Not Available
Hypotension24.06.03.002--
Increased appetite14.03.01.003; 08.01.09.0270.000851%Not Available
Insomnia19.02.01.002; 17.15.03.0020.001987%
Joint swelling15.01.02.0040.000284%Not Available
Malaise08.01.01.003--
Memory impairment17.03.02.003; 19.20.01.0030.001277%
Mental impairment19.21.02.003; 17.03.03.0020.000284%Not Available
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