Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tiotropium
Drug ID BADD_D02443
Description Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L7087,L7090,L7093] Tiotropium is more specific for the subset of muscarinic receptors commonly found in the lungs than [ipratropium].[A180163] Tiotropium was granted FDA approval on 30 January 2004.[L7084]
Indications and Usage Used in the management of chronic obstructive pulmonary disease (COPD).
Marketing Status Not Available
ATC Code R03BB04
DrugBank ID DB01409
KEGG ID D01929
MeSH ID D000069447
PubChem ID 5487427
TTD Drug ID D0P1WA
NDC Product Code Not Available
Synonyms Tiotropium Bromide | Bromide, Tiotropium | 7-((hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane bromide | Tiotropium | Spiriva | BA 679 BR | 679 BR, BA | BR, BA 679 | BA-679 BR | BA679 BR
Chemical Information
Molecular Formula C19H22NO4S2+
CAS Registry Number 186691-13-4
SMILES C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypotension24.06.03.002--
Hypoxia22.02.02.0030.000852%
Ileus07.13.01.0010.000608%
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Interstitial lung disease22.01.02.003; 10.02.01.033--Not Available
Intestinal obstruction07.13.01.0020.000608%Not Available
Intraocular pressure increased13.07.04.0020.000243%Not Available
Iron deficiency anaemia14.13.02.001; 01.03.01.0020.000243%Not Available
Irritability19.04.02.013; 08.01.03.011--
Jaundice01.06.04.004; 23.03.03.030; 09.01.01.004--Not Available
Joint swelling15.01.02.004--Not Available
Kidney infection20.01.09.004; 11.01.14.0060.000243%
Lacrimation increased06.08.02.0040.000365%
Lactic acidosis14.01.01.002--Not Available
Laryngeal oedema10.01.05.003; 22.04.02.001; 23.04.01.0050.000608%
Lethargy19.04.04.004; 17.02.04.003; 08.01.01.008--
Leukocytosis01.02.01.002--
Lip swelling23.04.01.007; 10.01.05.005; 07.05.04.005--Not Available
Liver disorder09.01.08.001--Not Available
Liver function test abnormal13.03.01.013--Not Available
Local swelling08.01.03.0130.000365%Not Available
Loss of consciousness17.02.04.0040.002069%Not Available
Lower respiratory tract infection22.07.01.002; 11.01.09.0020.001947%Not Available
Lung disorder22.02.07.0010.001947%Not Available
Lymphadenopathy01.09.01.0020.000365%Not Available
Lymphoma16.20.01.001; 01.12.01.0010.000063%Not Available
Macular degeneration06.09.03.0010.000852%Not Available
Malaise08.01.01.003--
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