Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tiotropium
Drug ID BADD_D02443
Description Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L7087,L7090,L7093] Tiotropium is more specific for the subset of muscarinic receptors commonly found in the lungs than [ipratropium].[A180163] Tiotropium was granted FDA approval on 30 January 2004.[L7084]
Indications and Usage Used in the management of chronic obstructive pulmonary disease (COPD).
Marketing Status Not Available
ATC Code R03BB04
DrugBank ID DB01409
KEGG ID D01929
MeSH ID D000069447
PubChem ID 5487427
TTD Drug ID D0P1WA
NDC Product Code Not Available
Synonyms Tiotropium Bromide | Bromide, Tiotropium | 7-((hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(3.3.1.0(2,4))nonane bromide | Tiotropium | Spiriva | BA 679 BR | 679 BR, BA | BR, BA 679 | BA-679 BR | BA679 BR
Chemical Information
Molecular Formula C19H22NO4S2+
CAS Registry Number 186691-13-4
SMILES C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bronchitis22.07.01.001; 11.01.09.0010.002190%
Bronchospasm22.03.01.004; 10.01.03.0120.000730%
Bronchospasm paradoxical22.03.01.0060.000365%Not Available
Burning sensation17.02.06.001; 08.01.09.0290.000973%Not Available
C-reactive protein increased13.09.01.0070.000487%Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.0010.000635%
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000317%Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.0010.000190%Not Available
Carpal tunnel syndrome17.09.02.0010.000243%Not Available
Cataract06.06.01.0010.000973%
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebral haemorrhage24.07.04.001; 17.08.01.003--Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.001095%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.0090.005232%Not Available
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.0020.002799%Not Available
Choking22.02.05.0010.002677%Not Available
Choking sensation22.02.05.002; 19.01.02.0020.000365%Not Available
Cholecystitis acute09.03.01.0030.000365%Not Available
Cholelithiasis09.03.01.002--Not Available
Choluria20.02.01.0210.000243%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.008857%Not Available
Circulatory collapse24.06.02.0010.000365%Not Available
Colon cancer16.13.01.001; 07.21.01.0010.000095%Not Available
Coma17.02.09.001--Not Available
Completed suicide08.04.01.010; 19.12.01.001--Not Available
Concussion17.11.01.004; 12.01.10.0050.000243%Not Available
Confusional state19.13.01.001; 17.02.03.005--
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