Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Enoxaparin
Drug ID BADD_D02438
Description Enoxaparin is a common low-molecular-weight heparin (LMWH) used in the prevention and management of various thromboembolic disorders. Initially approved by the FDA in 1993, it is administered by a subcutaneous or intravenous injection and marketed by several pharmaceutical companies.[L31393] Enoxaparin markedly reduces the incidence of venous thromboembolism in hospitalized patients when compared to unfractionated [heparin], without increasing the risk of serious bleeding.[A228178,A228313]
Indications and Usage For the prophylaxis of deep vein thrombosis, which may lead to pulmonary embolism, and also for the prophylaxis of ischemic complications of unstable angina and non-Q-wave myocardial infarction, when concurrently administered with aspirin.
Marketing Status Not Available
ATC Code B01AB01; B01AB12; C05BA03; S01XA14
DrugBank ID DB01225
KEGG ID D07510
MeSH ID D017984
PubChem ID 772
TTD Drug ID Not Available
NDC Product Code Not Available
Synonyms Enoxaparin | Enoxaparine | PK-10,169 | PK 10,169 | PK10,169 | PK-10169 | PK 10169 | PK10169 | EMT-967 | EMT 967 | EMT967 | Lovenox | Clexane | EMT-966 | EMT 966 | EMT966
Chemical Information
Molecular Formula C26H42N2O37S5
CAS Registry Number 9005-49-6
SMILES CC(=O)NC1C(C(C(OC1O)COS(=O)(=O)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)OC4C(C(C( C(O4)C(=O)O)O)O)OS(=O)(=O)O)OS(=O)(=O)O)NS(=O)(=O)O)O)OS(=O)(=O)O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Neutrophil count decreased13.01.06.010--
Normochromic normocytic anaemia01.03.02.0050.001049%Not Available
Oedema14.05.06.010; 08.01.07.0060.006296%Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007--
Oligohydramnios18.05.01.0010.001049%Not Available
Oliguria20.01.03.0040.002099%Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.0200.001049%Not Available
Osteonecrosis24.04.05.004; 15.02.04.0070.001049%
Osteoporosis15.02.03.002; 14.04.04.0020.001574%
Ovarian hyperstimulation syndrome05.05.01.013; 21.11.02.0070.002623%Not Available
Oxygen saturation decreased13.02.01.0040.002623%Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Pallor24.03.04.001; 23.03.03.031; 08.01.03.0320.003148%Not Available
Palpitations02.01.02.003--
Pancreatitis acute07.18.01.0020.001574%Not Available
Pancytopenia01.03.03.0030.003673%Not Available
Papule23.03.03.0380.001574%Not Available
Paraesthesia17.02.06.005--
Paralysis17.01.04.0040.001049%Not Available
Paraparesis17.01.04.0060.000547%Not Available
Paraplegia17.01.04.0070.001232%Not Available
Pelvic pain21.10.01.001; 20.02.03.007; 07.01.06.0120.001049%
Pelvic venous thrombosis24.01.02.0080.001574%Not Available
Pericardial effusion02.06.01.002--
Pericardial haemorrhage24.07.01.013; 02.06.01.0030.001049%Not Available
Peripheral coldness24.04.03.006; 08.01.09.0100.001574%Not Available
Peripheral ischaemia24.04.03.0020.001574%
Peritoneal haemorrhage07.07.02.001; 24.07.02.0160.000821%Not Available
Peroneal nerve palsy17.09.02.0030.001049%Not Available
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