Adverse Drug Reaction Classification System

         

Pharmaceutical Information
Drug Name Cinacalcet
Drug ID BADD_D02434
Description Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Indications and Usage For the treatment of secondary hyperparathyroidism in patients with Chronic Kidney Disease who are on hemodialysis or peritoneal dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma.
Marketing Status approved
ATC Code H05BX01
DrugBank ID DB01012
KEGG ID D03504
MeSH ID D000069449
PubChem ID 156419
TTD Drug ID D03YGR
NDC Product Code 72865-150; 72865-151; 72865-152; 42291-459; 65862-832; 16714-080; 42291-461; 67877-504; 68180-228; 42543-962; 47335-600; 51407-297; 63629-8765; 63629-8764; 63629-9607; 64380-885; 67877-503; 69097-410; 69097-412; 47335-380; 50268-153; 51407-296; 76282-674; 76282-675; 16729-440; 16729-441; 31722-104; 65162-155; 65162-213; 67877-505; 42291-460; 42543-961; 43598-368; 65162-157; 65862-831; 69097-411; 43598-369; 63629-8763; 63629-9606; 63629-9608; 65862-833; 68180-226; 31722-103; 47335-379; 60687-525; 64380-883; 68180-227; 76282-676; 0904-7067; 31722-105; 43598-367; 64380-884; 16729-442; 42543-963; 51407-295
UNII UAZ6V7728S
Synonyms Cinacalcet | Cinacalcet Hydrochloride | Alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride | Sensipar | AMG 073 | KRN 1493 | AMG073
Chemical Information
Molecular Formula C22H22F3N
CAS Registry Number 226256-56-0
SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Mass08.03.05.0030.002385%Not Available
Mastication disorder15.03.05.022; 17.05.03.006; 07.01.06.0160.032875%Not Available
Muscle spasms15.05.03.0040.257140%
Muscle twitching15.05.03.0050.008835%Not Available
Myalgia15.05.02.0010.047925%
Nausea07.01.07.0010.738623%
Nephrocalcinosis20.04.01.0010.001564%Not Available
Nerve compression17.09.02.002; 12.01.12.0010.001720%Not Available
Nipple pain21.05.05.0090.001329%Not Available
Pancreatic disorder07.18.02.0010.001055%Not Available
Pancreatitis07.18.01.001--
Papillary thyroid cancer16.24.03.002; 05.02.05.0050.000391%Not Available
Paraesthesia23.03.03.094; 17.02.06.0050.121651%
Parathyroid disorder05.04.03.0010.008014%Not Available
Parathyroid tumour benign05.04.03.003; 16.37.02.0020.004886%Not Available
Poor peripheral circulation24.04.03.0130.002385%Not Available
Pre-eclampsia24.08.07.002; 20.01.08.002; 18.02.03.0020.000586%Not Available
Renal cyst20.01.04.001; 16.27.01.0010.000586%Not Available
Renal failure20.01.03.005--Not Available
Renal haemorrhage20.01.02.013; 12.01.05.004; 24.07.07.0020.000586%
Retching07.01.07.0020.006176%Not Available
Sacroiliitis10.02.01.104; 15.01.01.0120.000586%Not Available
Sarcoidosis10.02.06.0010.000586%Not Available
Seizure17.12.03.0010.023337%
Skin ulcer24.04.03.007; 23.07.03.0030.004026%
Supraventricular extrasystoles02.03.03.0110.000391%Not Available
Tetany05.04.02.003; 14.04.01.005; 15.05.03.0130.000782%Not Available
Throat tightness22.12.03.031; 19.01.02.0050.003284%Not Available
Thyroid disorder05.02.01.0020.003166%Not Available
Ulcer08.03.06.0010.002033%Not Available
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