Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Cinacalcet
Drug ID BADD_D02434
Description Cinacalcet is a calcimimetic sold by Amgen under the trade name Sensipar® in North America and Australia and as Mimpara® in Europe. It is used to treat hyperparathyroidism due to parathyroid tumours or renal failure.
Indications and Usage For the treatment of secondary hyperparathyroidism in patients with Chronic Kidney Disease who are on hemodialysis or peritoneal dialysis. Also for the treatment of hypercalcemia in patients with parathyroid carcinoma.
Marketing Status Not Available
ATC Code H05BX01
DrugBank ID DB01012
KEGG ID D03504
MeSH ID D000069449
PubChem ID 156419
TTD Drug ID D03YGR
NDC Product Code 51407-297; 43598-368; 42291-461; 72865-152; 50268-153; 47335-379; 42291-459; 65162-213; 16714-079; 31722-104; 63629-8763; 42291-460; 64380-885; 67877-505; 68180-227; 68180-228; 72865-151; 65162-155; 16729-440; 63629-8765; 43598-367; 31722-103; 16714-080; 31722-105; 16729-441; 69097-410; 60687-525; 69097-412; 16714-078; 65862-831; 72865-150; 65862-833; 47335-380; 69097-411; 47335-600; 76282-676; 51407-296; 42543-961; 0904-7067; 65862-832; 76282-674; 64380-883; 64380-884; 42543-962; 43598-369; 51407-295; 67877-503; 67877-504; 42543-963; 68180-226; 76282-675; 65162-157; 63629-8764; 16729-442
Synonyms Cinacalcet | Cinacalcet Hydrochloride | Alpha-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-1-naphthalenemethanamine, (alphaR)-hydrochloride | Sensipar | AMG 073 | KRN 1493 | AMG073
Chemical Information
Molecular Formula C22H22F3N
CAS Registry Number 226256-56-0
SMILES CC(C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Burning sensation08.01.09.029; 17.02.06.001--Not Available
Cardiac arrest02.03.04.001--
Cardiac failure02.05.01.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.001--Not Available
Carpal tunnel syndrome17.09.02.001--Not Available
Cataract06.06.01.001--
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Cerebral thrombosis24.01.04.003; 17.08.01.0060.001792%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest discomfort22.02.08.001; 08.01.08.019; 02.02.02.009--Not Available
Chest pain02.02.02.011; 22.02.08.003; 08.01.08.002--Not Available
Chills15.05.03.016; 08.01.09.001--
Choking22.02.05.001--Not Available
Cholelithiasis09.03.01.002--Not Available
Chromaturia20.02.01.002--
Chronic obstructive pulmonary disease22.03.01.007--Not Available
Coagulopathy01.01.02.001--Not Available
Cold sweat23.02.03.002; 08.01.03.024--Not Available
Colitis07.08.01.001--
Colon cancer16.13.01.001; 07.21.01.001--Not Available
Coma17.02.09.001--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis11.01.06.012; 06.04.01.002--
Constipation07.02.02.0010.153188%
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Coronary artery occlusion24.04.04.013; 02.02.01.006--Not Available
Cough22.02.03.001--
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.005--Not Available
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