Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Colesevelam
Drug ID BADD_D02431
Description Colesevelam is a bile acid sequestrant. Colesevelam is used with exercise and diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and certain fatty substances in the blood. It works by binding bile acids in the intestine. Bile acids are made when cholesterol is broken down in the body. Removing these bile acids helps to lower blood cholesterol.
Indications and Usage For use, alone or in combination with an HMG-CoA reductase inhibitor, as adjunctive therapy to diet and exercise for the reduction of elevated LDL cholesterol in patients with primary hypercholesterolemia (Fredrickson Type IIa).
Marketing Status Not Available
ATC Code C10AC04
DrugBank ID DB00930
KEGG ID D07743
MeSH ID D000069472
PubChem ID 160051
TTD Drug ID D01YVT
NDC Product Code 70771-1368; 68382-619
Synonyms Colesevelam Hydrochloride | Hydrochloride, Colesevelam | Colesevelam HCl | HCl, Colesevelam | CholestaGel | Welchol | Colesevelam | GT 31104 | 31104, GT | GT-31104 | GT31-104 | GT31 104 | GT31104
Chemical Information
Molecular Formula C31H67Cl3N4O
CAS Registry Number 182815-44-7
SMILES CCCCCCCCCCNCC=C.C[N+](C)(C)CCCCCCNCC=C.C=CCN.C1C(O1)CCl.Cl.[Cl-]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.0160.001221%Not Available
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pruritus23.03.12.0010.002443%
Rash23.03.13.001--Not Available
Renal failure20.01.03.0050.000319%Not Available
Retching07.01.07.0020.001832%Not Available
Rhabdomyolysis15.05.05.0020.001221%
Rhinorrhoea22.02.05.0100.001221%
Swelling face23.04.01.018; 10.01.05.0180.001221%Not Available
Throat irritation22.02.05.013; 07.05.03.0040.001221%Not Available
Tinnitus17.04.07.004; 04.04.01.0020.001221%
Urticaria10.01.06.001; 23.04.02.0010.001832%
Vomiting07.01.07.0030.005497%
Weight decreased13.15.01.0050.004275%
Weight increased13.15.01.0060.003664%
Musculoskeletal stiffness15.03.01.0050.001221%Not Available
Restless legs syndrome17.02.07.008; 15.05.03.0120.001221%Not Available
Hot flush08.01.03.027; 24.03.01.005; 21.02.02.0010.001221%
Unevaluable event08.01.03.0510.001832%Not Available
Bowel movement irregularity07.02.03.0030.001221%Not Available
Thyroid cancer16.24.03.001; 05.02.05.0010.001221%Not Available
Oropharyngeal pain22.02.05.022; 07.05.05.0040.003054%
Medication residue present13.15.01.0320.001221%Not Available
Catheterisation cardiac13.14.07.0030.001221%Not Available
Coeliac disease14.02.01.007; 10.04.04.012; 07.17.01.0080.001832%Not Available
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