Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Loperamide
Drug ID BADD_D02428
Description One of the long-acting synthetic antidiarrheals; it is not significantly absorbed from the gut, and has no effect on the adrenergic system or central nervous system, but may antagonize histamine and interfere with acetylcholine release locally.
Indications and Usage For the control and symptomatic relief of acute nonspecific diarrhea and of chronic diarrhea associated with inflammatory bowel disease or gastroenteritis. Also used for reducing the volume of discharge from ileostomies.
Marketing Status Not Available
ATC Code A07DA03
DrugBank ID DB00836
KEGG ID D08144
MeSH ID D008139
PubChem ID 3955
TTD Drug ID D0CS2F
NDC Product Code Not Available
Synonyms Loperamide | R-18553 | R 18553 | R18553 | Imodium | Loperamide Hydrochloride | Hydrochloride, Loperamide | Loperamide Monohydrochloride | Monohydrochloride, Loperamide
Chemical Information
Molecular Formula C29H33ClN2O2
CAS Registry Number 53179-11-6
SMILES CN(C)C(=O)C(CCN1CCC(CC1)(C2=CC=C(C=C2)Cl)O)(C3=CC=CC=C3)C4=CC=CC=C4
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.0010.002225%Not Available
Abdominal distension07.01.04.0010.002967%
Abdominal pain07.01.05.0020.005192%
Acidosis14.01.03.0020.002225%
Agitation19.06.02.001; 17.02.05.0120.002225%
Angioedema23.04.01.001; 10.01.05.0090.001483%Not Available
Anxiety19.06.02.0020.002225%
Arrhythmia02.03.02.0010.008901%Not Available
Asthenia08.01.01.001--Not Available
Atrioventricular block first degree02.03.01.0040.002225%
Blood magnesium decreased13.11.01.0080.001483%Not Available
Blood magnesium increased13.11.01.0090.002225%Not Available
Blood potassium decreased13.11.01.0100.002967%Not Available
Bradycardia02.03.02.0020.010384%Not Available
Cardiac arrest02.03.04.0010.006772%
Cardio-respiratory arrest22.02.06.007; 02.03.04.0020.000967%Not Available
Catatonia19.11.01.0010.001483%Not Available
Circulatory collapse24.06.02.0010.000387%Not Available
Coagulopathy01.01.02.0010.002225%Not Available
Coma17.02.09.0010.003709%Not Available
Confusional state17.02.03.005; 19.13.01.0010.005192%
Constipation07.02.02.0010.002225%
Death08.04.01.0010.004450%
Delirium19.13.02.0010.001483%
Dependence19.07.02.0030.002225%Not Available
Depressed level of consciousness17.02.04.0020.001483%
Diarrhoea07.02.01.0010.009642%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.004450%
Drug abuse19.07.02.0100.017608%Not Available
Drug dependence19.07.02.0090.001483%Not Available
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