Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Radium ra 223 dichloride
Drug ID BADD_D02406
Description Radium Ra 223 Dichloride is a radiopharmaceutical containing the radioisotope radium-223 that emits short range but high linear energy alpha particles. As a cation, radium mimics calicum and binds to hydroxyapatite, which is a bone mineral found in areas of high bone turnover as seen in bone metastases. It was first approved by the FDA in May 2013 and is currently marketed under the brand name Xofigo, which was formerly called Alpharadin. Xofigo is indicated in patients who have metastatic bone cancer that is symptomatic with no visceral metastases and patients who have prostate cancer that is castration resistant. The FDA label includes a warning that Radium Ra 223 Dichloride should not be used in women who are pregnant or may become pregnant due to the high risk of fetal harm.
Indications and Usage Not Available
Marketing Status Not Available
ATC Code V10XX03
DrugBank ID DB08913
KEGG ID D10398
MeSH ID C581106
PubChem ID Not Available
TTD Drug ID Not Available
NDC Product Code 50419-208
Synonyms radium Ra 223 dichloride | radium chloride Ra 223 | Xofigo
Chemical Information
Molecular Formula Not Available
CAS Registry Number 444811-40-9
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Musculoskeletal pain15.03.04.007--
Myalgia15.05.02.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
Myocardial ischaemia24.04.04.010; 02.02.02.008-Not Available
Nausea07.01.07.001--
Neutropenia01.02.03.004--Not Available
Neutrophil count decreased13.01.06.010-
Neutrophil count increased13.01.06.011--Not Available
Oedema14.05.06.010; 08.01.07.006--Not Available
Oedema peripheral14.05.06.011; 08.01.07.007; 02.05.04.007-
Osteomyelitis11.01.01.001; 15.02.05.001-
Osteonecrosis15.02.04.007; 24.04.05.004-
Osteosclerosis15.02.04.012-Not Available
Pain08.01.08.004-
Pain in extremity15.03.04.010--
Pain in jaw15.02.01.003-Not Available
Pallor08.01.03.032; 24.03.04.001; 23.03.03.031-Not Available
Palpitations02.01.02.003--
Pancytopenia01.03.03.003-Not Available
Pathological fracture16.32.03.007; 15.08.02.008; 12.04.02.006-Not Available
Pelvic pain21.10.01.001; 20.02.03.007; 07.01.06.012--
Peritonsillar abscess11.01.13.014; 22.07.03.016-Not Available
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.016-Not Available
Plasma cell myeloma16.23.02.004; 01.14.02.004--Not Available
Platelet count decreased13.01.04.001-
Platelet disorder01.08.03.001-Not Available
Pleural effusion22.05.02.002-
Pneumonia22.07.01.003; 11.01.09.003--Not Available
Pneumonia aspiration22.01.01.005-Not Available
Pre-existing condition improved08.01.03.043-Not Available
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