Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Zolmitriptan
Drug ID BADD_D02393
Description Zolmitriptan is a member of the triptan class of 5-hydroxytryptamine(5-HT)1B/1D/(1F) receptor agonists used to treat acute migraine.[A462, L12978] [Sumatriptan] was the first triptan to be developed, but had poor oral bioavailability and lipophilicity. This led to the development of second-generation triptans, including [almotriptan], [eletriptan], [frovatriptan], [naratriptan], [rizatriptan], and zolmitriptan.[A193791] Triptans can be administered alone or in combination with an NSAID like [naproxen], and represent the current "gold standard" for acute migraine treatment.[A193797] Zolmitriptan was first approved by the FDA for sale by Zeneca Pharmaceuticals under the trade name Zomig® on November 25, 1997. It is currently available in both tablet and nasal spray forms.[L12978]
Indications and Usage For the acute treatment of adult migraine with or without auras.
Marketing Status Prescription; Discontinued
ATC Code N02CC03
DrugBank ID DB00315
KEGG ID D00415
MeSH ID C089750
PubChem ID 60857
TTD Drug ID D0NG7O
NDC Product Code 69097-863; 68382-715; 69097-864; 64896-671; 54864-955; 64896-681; 65862-915; 64896-691; 68462-497; 68382-717; 64980-203; 11722-012; 59746-462; 50742-625; 55700-944; 46708-182; 55111-800; 63548-0101; 59746-433; 64896-672; 46708-181; 65862-914; 63850-4322; 63548-0102; 68001-250; 55700-943; 16571-804; 65841-768; 68382-712; 27241-022; 45802-711; 16571-803; 46708-462; 46708-463; 68001-249; 59746-461; 64980-257; 65862-801; 67835-5007; 64896-692; 64896-682; 65977-0050; 65841-766; 69238-2006; 68462-500; 71626-102; 64980-204; 71626-101; 50742-626; 65841-767; 68462-498; 65841-765; 72606-568; 64980-256; 68382-714; 72606-567; 68462-499; 65015-688; 69238-2007; 59746-432; 66039-845; 64567-0016; 46708-898; 65372-1145; 27241-021
Synonyms zolmitriptan | 4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone | Zomig | AscoTop | Zomigoro | 311C90 | Flezol
Chemical Information
Molecular Formula C16H21N3O2
CAS Registry Number 139264-17-8
SMILES CN(C)CCC1=CNC2=C1C=C(C=C2)CC3COC(=O)N3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal distension07.01.04.0010.007757%
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.0030.007757%
Abnormal dreams19.02.03.001; 17.15.02.001--Not Available
Abortion spontaneous18.01.04.001--Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.0010.003103%Not Available
Agitation19.06.02.001; 17.02.05.012--
Akathisia19.06.02.006; 17.01.02.002--
Amblyopia06.02.01.001--Not Available
Amnesia19.20.01.001; 17.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.003103%
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Anaphylactoid reaction24.06.03.007; 10.01.07.003--Not Available
Angina pectoris02.02.02.002; 24.04.04.002--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Angle closure glaucoma06.03.01.0010.006206%Not Available
Anxiety19.06.02.002--
Apathy19.04.04.002--Not Available
Apnoea22.02.01.001--
Arrhythmia02.03.02.001--Not Available
Arteriospasm coronary02.02.02.005; 24.04.04.0050.004654%Not Available
Arthralgia15.01.02.0010.006206%
Arthritis15.01.01.001--
Arthropathy15.01.01.003--Not Available
Asthenia08.01.01.001--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Atrial fibrillation02.03.03.002--
Back pain15.03.04.005--
Bladder pain20.02.02.001--Not Available
Blood pressure increased13.14.03.0050.003103%Not Available
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