Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Zoledronic acid
Drug ID BADD_D02392
Description Zoledronic acid, or CGP 42'446,[A203120] is a third generation, nitrogen containing bisphosphonate similar to [ibandronic acid], [minodronic acid], and [risedronic acid].[A203111] Zoledronic acid is used to treat and prevent multiple forms of osteoporosis, hypercalcemia of malignancy, multiple myeloma, bone metastases from solid tumors, and Paget’s disease of bone.[L13712,L13715,L13721] Zoledronic acid was first described in the literature in 1994.[A203120] Zoledronic acid was granted FDA approval on 20 August 2001.[L13712]
Indications and Usage For the treatment of hypercalcemia of malignancy. Also for the treatment of patients with multiple myeloma and patients with documented bone metastases from solid tumors, in conjunction with standard antineoplastic therapy. In May of 2007, the drug was approved for treatment of Paget’s Disease.
Marketing Status Prescription; Discontinued
ATC Code M05BA08
DrugBank ID DB00399
KEGG ID D01968
MeSH ID D000077211
PubChem ID 68740
TTD Drug ID D0VM2L
NDC Product Code 70860-802; 43598-255; 42533-102; 67457-794; 65797-0006; 65129-1144; 55111-688; 0078-0435; 67457-920; 50742-416; 55150-266; 54288-100; 55111-685; 0409-4215; 60505-6110; 16714-815; 68001-437; 55150-283; 25021-830; 65372-1117; 25021-826; 14593-836; 16729-242; 0143-9642; 57741-2600; 51991-065; 68001-366; 68083-142; 53104-7622; 25021-801; 43598-331; 17478-324; 70860-210; 63323-966; 68554-0037; 43598-330; 63126-906; 63759-0012; 62147-0125; 67457-619; 68083-116; 63850-7104; 68083-256; 17478-327; 68083-135; 63323-961; 67457-390
Synonyms Zoledronic Acid | 2-(Imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid | CGP 42446A | CGP-42446 | CGP 42446 | CGP42446 | CGP-42'446 | CGP42'446 | CGP 42'446 | Zometa | Zoledronic Acid Anhydrous | Zoledronate
Chemical Information
Molecular Formula C5H10N2O7P2
CAS Registry Number 118072-93-8
SMILES C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal distension07.01.04.001--
Abdominal pain07.01.05.002--
Abdominal pain lower07.01.05.010--Not Available
Abdominal pain upper07.01.05.003--
Abdominal tenderness07.01.05.0040.013122%Not Available
Abscess11.01.08.0010.209947%Not Available
Acidosis14.01.03.0020.013122%
Acute respiratory distress syndrome22.01.03.001--
Acute respiratory failure22.02.06.001; 14.01.04.004--Not Available
Acute sinusitis22.07.03.013; 11.01.13.0120.032804%Not Available
Adenocarcinoma16.16.01.0040.006846%Not Available
Aggression19.05.01.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Agranulocytosis01.02.03.001--Not Available
Alanine aminotransferase increased13.03.01.003--
Alopecia23.02.02.001--
Altered state of consciousness19.07.01.003; 17.02.04.0010.052487%Not Available
Aminoaciduria20.02.01.024; 14.14.04.003; 03.08.04.0030.019683%Not Available
Amnesia17.03.02.001; 19.20.01.001--
Amyotrophic lateral sclerosis17.05.05.0040.013122%Not Available
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Anaphylactic shock24.06.02.004; 10.01.07.002--Not Available
Angina unstable24.04.04.004; 02.02.02.004--Not Available
Angioedema10.01.05.009; 23.04.01.001--Not Available
Anhedonia19.15.02.007--Not Available
Ankle fracture15.08.03.005; 12.04.01.0050.085291%
Anuria20.01.03.0020.065609%Not Available
Anxiety19.06.02.002--
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