Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Voriconazole
Drug ID BADD_D02369
Description Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections.[L15571] It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [fluconazole]-resistant organisms.[A236050] Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.[L34660]
Indications and Usage For the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.
Marketing Status Prescription
ATC Code J02AC03
DrugBank ID DB00582
KEGG ID D00578
MeSH ID D065819
PubChem ID 71616
TTD Drug ID D0N3VR
NDC Product Code 0904-6596; 0049-3180; 40032-089; 70966-0030; 65841-831; 43547-378; 0049-4190; 0904-6471; 0781-5668; 0395-8230; 27241-062; 72266-131; 68462-573; 70710-1247; 51552-1524; 0378-1640; 60715-1700; 0781-5667; 40032-038; 65862-891; 60687-294; 43547-377; 43386-088; 51407-133; 53296-0081; 63629-8734; 43386-089; 0049-3170; 65862-916; 65841-830; 66039-951; 60687-273; 59762-0935; 70771-1413; 0049-3190; 58032-2007; 0378-1626; 14501-0014; 63739-008; 68462-572; 16436-0081; 72969-077; 51079-165; 27241-063; 64980-274; 65015-801; 51552-1573; 52562-001; 72578-063; 0904-7024; 65862-892; 63126-911; 65219-190; 72578-062; 0781-3416; 70436-029; 64220-140; 59762-0936; 16714-199; 68083-321; 65372-1175; 51079-164; 59762-0934; 43386-038; 64980-275; 66039-876; 39822-1077; 0049-3160; 68554-0111; 40032-088; 71052-149; 65162-913; 47781-466; 73223-005; 16714-198; 55111-099
Synonyms Voriconazole | UK 109,496 | UK-109,496 | UK109,496 | UK-109496 | UK109496 | UK 109496 | Vfend
Chemical Information
Molecular Formula C16H14F3N5O
CAS Registry Number 188416-29-7
SMILES CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood creatinine increased13.13.01.004--
Blood glucose increased13.02.02.002--Not Available
Blood lactate dehydrogenase increased13.04.02.0020.053245%
Blood pressure decreased13.14.03.0020.119801%Not Available
Blood pressure increased13.14.03.005--Not Available
Blood urea increased13.13.01.006--Not Available
Blood uric acid increased13.02.04.001--Not Available
Body temperature increased13.15.01.001--Not Available
Bone disorder15.02.04.0040.026622%Not Available
Bone pain15.02.01.0010.359402%
Bowen's disease23.08.02.004; 16.03.02.0040.079867%Not Available
Bradycardia02.03.02.0020.133112%Not Available
Brain abscess17.06.07.001; 11.01.03.0030.053245%Not Available
Bronchiectasis22.03.02.0050.026622%Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchopulmonary aspergillosis22.07.08.001; 11.03.01.0020.086812%Not Available
Bundle branch block02.03.01.009--Not Available
Burning sensation17.02.06.001; 08.01.09.029--Not Available
Cardiac arrest02.03.04.0010.052087%
Cardiac failure02.05.01.0010.097230%
Cardiac failure congestive02.05.01.002--Not Available
Cardio-respiratory arrest22.02.06.007; 02.03.04.002--Not Available
Cardiomegaly02.04.02.001--Not Available
Cardiomyopathy02.04.01.001--Not Available
Cataract06.06.01.001--
Cellulitis23.09.01.001; 11.02.01.0010.066556%Not Available
Cerebral haemorrhage17.08.01.003; 24.07.04.001--Not Available
Cerebral infarction24.04.06.002; 17.08.01.004--Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.005--
Cerebrovascular accident24.03.05.001; 17.08.01.007--
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