Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Voriconazole
Drug ID BADD_D02369
Description Voriconazole (Vfend, Pfizer) is a triazole antifungal medication used to treat serious fungal infections.[L15571] It is used to treat invasive fungal infections that are generally seen in patients who are immunocompromised. These include invasive candidiasis, invasive aspergillosis, and emerging fungal infections. The increased affinity of voriconazole for 14-alpha sterol demethylase makes it useful against some [fluconazole]-resistant organisms.[A236050] Voriconazole was approved by the FDA under the trade name Vfend on May 24, 2002.[L34660]
Indications and Usage For the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp.
Marketing Status Prescription
ATC Code J02AC03
DrugBank ID DB00582
KEGG ID D00578
MeSH ID D065819
PubChem ID 71616
TTD Drug ID D0N3VR
NDC Product Code 0904-6596; 0049-3180; 40032-089; 70966-0030; 65841-831; 43547-378; 0049-4190; 0904-6471; 0781-5668; 0395-8230; 27241-062; 72266-131; 68462-573; 70710-1247; 51552-1524; 0378-1640; 60715-1700; 0781-5667; 40032-038; 65862-891; 60687-294; 43547-377; 43386-088; 51407-133; 53296-0081; 63629-8734; 43386-089; 0049-3170; 65862-916; 65841-830; 66039-951; 60687-273; 59762-0935; 70771-1413; 0049-3190; 58032-2007; 0378-1626; 14501-0014; 63739-008; 68462-572; 16436-0081; 72969-077; 51079-165; 27241-063; 64980-274; 65015-801; 51552-1573; 52562-001; 72578-063; 0904-7024; 65862-892; 63126-911; 65219-190; 72578-062; 0781-3416; 70436-029; 64220-140; 59762-0936; 16714-199; 68083-321; 65372-1175; 51079-164; 59762-0934; 43386-038; 64980-275; 66039-876; 39822-1077; 0049-3160; 68554-0111; 40032-088; 71052-149; 65162-913; 47781-466; 73223-005; 16714-198; 55111-099
Synonyms Voriconazole | UK 109,496 | UK-109,496 | UK109,496 | UK-109496 | UK109496 | UK 109496 | Vfend
Chemical Information
Molecular Formula C16H14F3N5O
CAS Registry Number 188416-29-7
SMILES CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Persecutory delusion19.10.01.0070.026622%Not Available
Pulmonary mycosis22.07.08.013; 11.03.05.0270.053245%Not Available
Corneal bleeding06.07.01.005; 24.07.05.0120.053245%Not Available
Cerebral aspergillosis17.06.09.004; 11.03.01.0050.013890%Not Available
Fusarium infection11.03.05.0220.010417%Not Available
Brain natriuretic peptide increased13.02.04.0110.026622%Not Available
Trichosporon infection11.03.05.0310.006945%Not Available
Cell death14.11.02.005; 08.03.03.0030.079867%Not Available
Subacute cutaneous lupus erythematosus23.03.02.020; 15.06.02.012; 10.04.03.0120.053245%Not Available
Acute myeloid leukaemia recurrent16.01.05.004; 01.10.05.0040.006945%Not Available
Scedosporium infection11.03.05.0290.026622%Not Available
Klebsiella infection11.02.03.0030.053245%Not Available
Antibiotic level below therapeutic13.17.01.0160.026622%Not Available
Keratitis fungal11.03.05.023; 06.04.02.0120.026622%Not Available
Leukaemia recurrent16.01.03.005; 01.10.03.0050.017362%Not Available
Mycotic endophthalmitis11.03.05.025; 06.04.05.0290.252912%Not Available
Metastatic squamous cell carcinoma16.16.01.0100.010417%Not Available
Mucosal necrosis08.01.06.0230.010417%Not Available
Aspergillus test positive13.08.06.0030.079867%Not Available
Disorganised speech19.19.02.005; 17.02.08.0170.039934%Not Available
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