Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vincristine sulfate
Drug ID BADD_D02361
Description Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
Indications and Usage Treatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms' tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).
Marketing Status Prescription; Discontinued
ATC Code L01CA02
DrugBank ID DB00541
KEGG ID D02197
MeSH ID D014750
PubChem ID 249332
TTD Drug ID D09QVV
NDC Product Code 53104-7505; 62158-0010; 0703-4412; 54087-329; 61703-309; 72893-008; 0703-4402
Synonyms Vincristine | Leurocristine | Vincristine Sulfate | Sulfate, Vincristine | cellcristin | Citomid | Vincristin medac | Oncovin | Oncovine | Onkocristin | Vincasar | Farmistin | Vincasar PFS | PFS, Vincasar | Vincristin Bristol | Vintec | Vincrisul
Chemical Information
Molecular Formula C46H56N4O10.H2O4S
CAS Registry Number 2068-78-2
SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8 N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O.OS(=O)(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Myalgia15.05.02.001--
Nausea07.01.07.001--
Neuralgia17.02.07.005--
Neuropathy peripheral17.09.03.003--Not Available
Neutropenia01.02.03.004--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Pain08.01.08.004--
Pain in jaw15.02.01.003--Not Available
Paraesthesia17.02.06.005--
Pneumonia11.01.09.003; 22.07.01.003--Not Available
Pulmonary haemorrhage24.07.01.016; 22.02.04.003--
Pyrexia08.05.02.003--
Respiratory distress22.02.01.012--Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Septic shock11.01.11.004; 24.06.02.011--Not Available
Thrombocytopenia01.08.01.002--Not Available
Tumour lysis syndrome14.05.01.004; 16.32.03.002--
Mental status changes19.07.01.001--Not Available
Musculoskeletal disorder15.03.01.004--Not Available
Sudden cardiac death08.04.01.008; 02.03.04.016--Not Available
Staphylococcal bacteraemia11.02.05.001--Not Available
Colonic pseudo-obstruction17.05.01.012; 07.02.02.008--Not Available
Connective tissue disorder15.06.01.006--Not Available
Cranial nerve disorder17.04.01.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Decreased vibratory sense17.02.07.013--Not Available
Multiple organ dysfunction syndrome08.01.03.057--
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