Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vincristine
Drug ID BADD_D02360
Description Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
Indications and Usage Treatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms' tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).
Marketing Status Prescription; Discontinued
ATC Code L01CA02
DrugBank ID DB00541
KEGG ID D08679
MeSH ID D014750
PubChem ID 5978
TTD Drug ID D09QVV
NDC Product Code Not Available
Synonyms Vincristine | Leurocristine | Vincristine Sulfate | Sulfate, Vincristine | cellcristin | Citomid | Vincristin medac | Oncovin | Oncovine | Onkocristin | Vincasar | Farmistin | Vincasar PFS | PFS, Vincasar | Vincristin Bristol | Vintec | Vincrisul
Chemical Information
Molecular Formula C46H56N4O10
CAS Registry Number 57-22-7
SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8 N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Erectile dysfunction21.03.01.007; 19.08.04.001--
Blood disorder01.05.01.004--Not Available
Autonomic neuropathy17.05.01.0090.001865%Not Available
Occult blood positive13.05.02.0010.000533%Not Available
Cranial nerve paralysis17.04.01.002--Not Available
Venoocclusive disease24.03.02.0160.000278%Not Available
Bone marrow failure01.03.03.0050.002398%
Decreased vibratory sense17.02.07.013--Not Available
Toxic neuropathy17.09.03.017; 12.03.01.0550.000799%Not Available
Posterior reversible encephalopathy syndrome17.13.02.0070.001066%
Drug-induced liver injury12.03.01.044; 09.01.07.0230.000533%Not Available
Pneumocystis jirovecii pneumonia22.07.08.009; 11.03.07.0050.000533%Not Available
Multiple organ dysfunction syndrome08.01.03.057--
Anal incontinence17.05.01.021; 07.01.06.0290.000533%
Mononeuropathy multiplex17.09.02.0120.002398%Not Available
Normal newborn18.08.06.0010.000533%Not Available
Squamous cell carcinoma of the cervix21.06.02.007; 16.12.01.0040.000799%Not Available
Hereditary motor and sensory neuropathy17.09.05.001; 03.10.05.0010.000799%Not Available
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