Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vincristine
Drug ID BADD_D02360
Description Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
Indications and Usage Treatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms' tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).
Marketing Status Prescription; Discontinued
ATC Code L01CA02
DrugBank ID DB00541
KEGG ID D08679
MeSH ID D014750
PubChem ID 5978
TTD Drug ID D09QVV
NDC Product Code Not Available
Synonyms Vincristine | Leurocristine | Vincristine Sulfate | Sulfate, Vincristine | cellcristin | Citomid | Vincristin medac | Oncovin | Oncovine | Onkocristin | Vincasar | Farmistin | Vincasar PFS | PFS, Vincasar | Vincristin Bristol | Vintec | Vincrisul
Chemical Information
Molecular Formula C46H56N4O10
CAS Registry Number 57-22-7
SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8 N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Vertigo04.04.01.003; 17.02.12.002--
Visual field defect17.17.01.001; 06.02.07.0030.000533%Not Available
Vocal cord paralysis22.04.01.002; 17.04.06.0020.001332%
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
White blood cell count decreased13.01.06.0120.001865%
White blood cell count increased13.01.06.0130.000533%Not Available
Mental status changes19.07.01.001--Not Available
Vocal cord paresis22.04.01.004; 17.04.06.0030.000533%Not Available
Sudden cardiac death08.04.01.008; 02.03.04.016--Not Available
Subileus07.13.01.0040.000533%Not Available
Staphylococcal bacteraemia11.02.05.0010.000533%Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Gastrointestinal hypomotility07.02.02.0050.000799%Not Available
Lymphatic disorder01.09.01.003--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Inappropriate antidiuretic hormone secretion14.05.07.001; 05.03.03.0010.000799%Not Available
Walking disability26.01.01.009--Not Available
Febrile bone marrow aplasia08.05.02.005; 01.03.03.0070.000556%Not Available
Transaminases increased13.03.01.0150.000533%Not Available
Colonic pseudo-obstruction07.02.02.008; 17.05.01.0120.001865%Not Available
Angiopathy24.03.02.007--Not Available
Urine output increased13.13.03.002--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Haematotoxicity12.03.01.025; 01.05.01.0070.000533%Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Neoplasm progression16.16.02.0050.000625%Not Available
Decreased appetite08.01.09.028; 14.03.01.005--
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