Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Vincristine
Drug ID BADD_D02360
Description Vincristine is an antitumor vinca alkaloid isolated from Vinca Rosea. It is marketed under several brand names, many of which have different formulations such as Marqibo (liposomal injection) and Vincasar. Vincristine is indicated for the treatment of acute leukaemia, malignant lymphoma, Hodgkin's disease, acute erythraemia, and acute panmyelosis. vincristine sulfate is often chosen as part of polychemotherapy because of lack of significant bone–marrow suppression (at recommended doses) and of unique clinical toxicity (neuropathy).
Indications and Usage Treatment of acute lymphocytic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphomas, Wilms' tumor, neuroblastoma, rhabdomyosarcoma. Liposomal vincristine is indicated for the treatment of relapsed Philadelphia chromosome-negative (Ph-) acute lymphoblastic leukemia (ALL).
Marketing Status Prescription; Discontinued
ATC Code L01CA02
DrugBank ID DB00541
KEGG ID D08679
MeSH ID D014750
PubChem ID 5978
TTD Drug ID D09QVV
NDC Product Code Not Available
Synonyms Vincristine | Leurocristine | Vincristine Sulfate | Sulfate, Vincristine | cellcristin | Citomid | Vincristin medac | Oncovin | Oncovine | Onkocristin | Vincasar | Farmistin | Vincasar PFS | PFS, Vincasar | Vincristin Bristol | Vintec | Vincrisul
Chemical Information
Molecular Formula C46H56N4O10
CAS Registry Number 57-22-7
SMILES CCC1(CC2CC(C3=C(CCN(C2)C1)C4=CC=CC=C4N3)(C5=C(C=C6C(=C5)C78CCN9C7C(C=CC9)(C(C(C8 N6C=O)(C(=O)OC)O)OC(=O)C)CC)OC)C(=O)OC)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Paraesthesia17.02.06.005--
Paralysis17.01.04.0040.000208%Not Available
Paresis17.01.04.008--Not Available
Peripheral motor neuropathy17.09.03.0040.000533%
Peroneal nerve palsy17.09.02.003--Not Available
Photosensitivity reaction23.03.09.003--
Pneumonia22.07.01.003; 11.01.09.0030.001332%Not Available
Polyneuropathy17.09.03.0120.000533%Not Available
Polyuria20.02.03.002--Not Available
Pulmonary haemorrhage24.07.01.016; 22.02.04.003--
Pyrexia08.05.02.0030.005062%
Quadriplegia17.01.04.0130.000799%Not Available
Rash23.03.13.001--Not Available
Respiratory distress22.02.01.012--Not Available
Respiratory failure22.02.06.002; 14.01.04.0030.000556%
Second primary malignancy16.16.01.0140.000556%
Seizure17.12.03.001--
Sensory loss17.02.07.007--Not Available
Septic shock24.06.02.011; 11.01.11.0040.000486%Not Available
Stomatitis07.05.06.0050.000533%
Tachycardia02.03.02.0070.000799%Not Available
Thrombocytopenia01.08.01.002--Not Available
Tumour lysis syndrome16.32.03.002; 14.05.01.0040.001066%
Urate nephropathy20.05.03.014; 14.09.01.008--Not Available
Urethral disorder20.07.01.002--Not Available
Urinary retention20.02.02.011--
Urinary tract disorder20.08.01.001--Not Available
Urine sodium increased13.11.01.048--Not Available
Urticaria10.01.06.001; 23.04.02.0010.000533%
Venoocclusive liver disease24.04.07.002; 09.01.06.0020.000533%
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