| Drug Name |
Vigabatrin |
| Drug ID |
BADD_D02355 |
| Description |
Vigabatrin is an analog of gamma-aminobutyric acid ([GABA]), the main inhibitory neurotransmitter in the central nervous system, used in the treatment of refractory seizures and infantile spasms.[L13616] It irreversibly inhibits the enzyme responsible for GABA metabolism, thereby increasing levels of circulating GABA. Although administered as a racemic mixture, only the S(+) enantiomer is pharmacologically active.[A202037]
It was first introduced as an antiepileptic agent in the United Kingdom in 1989 and was used extensively until 1997, when an association with vision loss became apparent.[A202124] Its use is now generally reserved for patients who have failed alternative therapies, and its US approval by the FDA in 2009 mandated the creation of a drug registry to monitor patients for visual deficits.[L13661,A202124] |
| Indications and Usage |
For use as an adjunct in treatment resistant epilepsy, refractory complex partial seizures, and secondary generalized seizures. It is also used as monotherapy in infantile spasms in West syndrome. |
| Marketing Status |
Prescription |
| ATC Code |
N03AG04 |
| DrugBank ID |
DB01080
|
| KEGG ID |
D00535
|
| MeSH ID |
D020888
|
| PubChem ID |
5665
|
| TTD Drug ID |
D0R3QY
|
| NDC Product Code |
67877-674; 0245-0556; 59651-366; 59651-364; 0591-3851; 76055-0033; 67651-0294; 0591-3955; 14501-0081; 68621-0046; 16729-521; 70771-1654; 43598-651; 68180-521; 0054-0702; 62331-042; 67386-111; 31722-009; 67386-211; 71886-434; 49884-358; 72158-101; 69238-1425; 69097-964; 43598-697; 65977-0106; 70710-1287; 62207-975 |
| Synonyms |
Vigabatrin | gamma-Vinyl-gamma-Aminobutyric Acid | gamma Vinyl gamma Aminobutyric Acid | gamma-Vinyl-GABA | gamma Vinyl GABA | Sabrilex | Sabril |
