Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Verapamil hydrochloride
Drug ID BADD_D02349
Description Verapamil is a phenylalkylamine calcium channel blocker used in the treatment of high blood pressure, heart arrhythmias, and angina,[L8791] and was the first calcium channel antagonist to be introduced into therapy in the early 1960s.[A188514] It is a member of the non-dihydropyridine class of calcium channel blockers, which includes drugs like [diltiazem] and [flunarizine], but is chemically unrelated to other cardioactive medications.[L8791] Verapamil is administered as a racemic mixture containing equal amounts of the S- and R-enantiomer, each of which is pharmacologically distinct - the S-enantiomer carries approximately 20-fold greater potency than the R-enantiomer, but is metabolized at a higher rate.[A188435]
Indications and Usage For the treatment of hypertension, angina, and cluster headache prophylaxis.
Marketing Status Prescription; Discontinued
ATC Code C08DA01
DrugBank ID DB00661
KEGG ID D00619
MeSH ID D014700
PubChem ID 62969
TTD Drug ID D0R0FE
NDC Product Code 68071-4635; 63629-7845; 68071-3072; 71209-048; 75834-159; 60274-100; 52584-271; 71872-7048; 71335-0041; 70518-1464; 68071-4663; 50090-0584; 60687-515; 0378-6380; 60274-240; 71872-7183; 63629-7893; 55150-342; 60274-180; 63629-8842; 50090-2595; 0025-2924; 50090-4013; 51662-1398; 71335-0271; 55289-723; 70934-688; 25021-312; 42571-313; 42291-853; 71205-129; 62175-487; 71335-0147; 0591-2880; 53002-1129; 0378-6320; 71610-268; 68071-2474; 0591-2884; 65015-750; 70771-1601; 55150-343; 0591-0343; 0591-2886; 0591-2882; 70518-1326; 51662-1270; 71872-7210; 0025-2818; 70934-902; 43066-031; 67296-0937; 0904-2920; 68462-292; 63629-7233; 62175-485; 17511-132; 0378-6440; 43063-561; 70518-2184; 68083-448; 62175-486; 0409-4011; 71872-7243; 60687-504; 0904-2924; 71335-1258; 0404-9968; 70069-271; 0409-1144; 71872-7203; 63629-7894; 0404-9966; 70710-1643; 62175-583; 68083-447; 70121-1586; 70069-273; 60274-200; 68788-6328; 62175-572; 43066-035; 51927-0173; 70771-1602; 70121-1585; 23155-059; 51754-0205; 60687-493; 43353-992; 70710-1644; 50090-0156; 68462-293; 71205-607; 60274-120; 52584-633; 72485-109; 53002-1205; 23155-026; 71610-377; 72485-108; 75834-158; 23155-486; 62175-570; 53002-1074; 70934-396; 51754-0204; 50090-5253; 0404-9967; 63629-4337; 60274-300; 59923-605; 0025-2712; 0591-0345; 51655-957; 68788-9790; 49452-8113; 50090-1400; 71335-1004; 62175-581; 72761-030; 53002-1467; 62175-582; 62175-580; 0591-0404; 52584-272; 42291-855; 71209-047; 38779-0275; 65145-114; 51927-1921; 0409-9633; 51079-917; 50090-4582; 70518-0605; 67296-1654; 12711-9279; 71335-1394; 42291-854; 71610-405; 70069-272; 71205-017; 65145-113; 63187-849; 66267-212; 61919-107; 60274-360; 51754-0203; 68462-260; 65085-0026; 71610-258; 62175-571; 68071-5257
Synonyms Verapamil | Iproveratril | Cordilox | Dexverapamil | Verapamil Hydrochloride | Hydrochloride, Verapamil | Finoptin | Izoptin | Isoptine | Isoptin | Lekoptin | Calan | Falicard
Chemical Information
Molecular Formula C27H39ClN2O4
CAS Registry Number 152-11-4
SMILES CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
Sudden cardiac deathSodium channel protein type 5 subunit alphaQ14524T39716Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily E member 1P15382Not AvailableNot Available
Sudden cardiac deathPotassium voltage-gated channel subfamily H member 2Q12809T20251Not Available
Sudden cardiac deathPotassium voltage-gated channel subfamily KQT member 1P51787T49526Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Alopecia23.02.02.001--
Angina pectoris24.04.04.002; 02.02.02.002--
Arthralgia15.01.02.001--
Atrioventricular block complete02.03.01.003--
Bradycardia02.03.02.002--Not Available
Cardiac failure congestive02.05.01.002--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Dyspnoea22.02.01.004; 02.01.03.002--
Ecchymosis24.07.06.002; 23.06.01.001; 01.01.03.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Extrapyramidal disorder17.01.02.007--
Fatigue08.01.01.002--
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Galactorrhoea21.05.02.002; 05.03.04.002--Not Available
Gingival hyperplasia07.09.03.002--Not Available
Gynaecomastia21.05.04.003; 05.05.02.003--
Headache17.14.01.001--
Heart rate13.14.04.012--Not Available
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hyperkeratosis23.01.01.001--
Hyperprolactinaemia05.03.01.002--Not Available
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
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