Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valdecoxib
Drug ID BADD_D02325
Description Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.
Indications and Usage For the treatment of osteoarthritis and dysmenorrhoea
Marketing Status Discontinued
ATC Code M01AH03
DrugBank ID DB00580
KEGG ID D02709
MeSH ID C406224
PubChem ID 119607
TTD Drug ID D0L6DA
NDC Product Code Not Available
Synonyms valdecoxib | Bextra | SC 65872 | SC-65872
Chemical Information
Molecular Formula C16H14N2O3S
CAS Registry Number 181695-72-7
SMILES CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Thrombophlebitis24.01.02.001--Not Available
Thrombosis24.01.01.006--Not Available
Tinnitus04.04.01.002; 17.04.07.004--
Tooth disorder07.09.05.001--Not Available
Toxic epidermal necrolysis23.03.01.008; 12.03.01.015; 11.07.01.006; 10.01.01.006--
Tremor17.01.06.002--
Upper respiratory tract infection11.01.13.009; 22.07.03.011--
Urinary incontinence17.05.01.008; 20.02.02.010--
Urinary tract infection20.08.02.001; 11.01.14.004--
Urticaria23.04.02.001; 10.01.06.001--
Vaginal discharge21.08.02.002--
Vaginal haemorrhage24.07.03.005; 21.08.01.001--
Varicose vein24.10.04.001--Not Available
Vasospasm24.04.02.002--Not Available
Ventricular fibrillation02.03.04.008--
Vertigo17.02.12.002; 04.04.01.003--
Viral infection11.05.04.001--Not Available
Vision blurred17.17.01.010; 06.02.06.007--
Visual impairment06.02.06.008--Not Available
Vomiting07.01.07.003--
Weight decreased13.15.01.005--
Weight increased13.15.01.006--
Xerophthalmia14.12.03.002; 06.06.03.008--Not Available
Acute coronary syndrome24.04.04.011; 02.02.02.015--Not Available
Musculoskeletal stiffness15.03.01.005--Not Available
Musculoskeletal discomfort15.03.04.001--Not Available
Haemorrhoidal haemorrhage24.10.02.001; 07.15.03.002--
Haemorrhage24.07.01.002--Not Available
Rectal tenesmus07.03.03.001; 15.05.03.011--Not Available
Lung neoplasm malignant22.08.01.001; 16.19.02.001--Not Available
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