Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Valdecoxib
Drug ID BADD_D02325
Description Valdecoxib was removed from the Canadian, U.S., and E.U. markets in 2005 due to concerns about a possible increased risk of heart attack and stroke.
Indications and Usage For the treatment of osteoarthritis and dysmenorrhoea
Marketing Status Discontinued
ATC Code M01AH03
DrugBank ID DB00580
KEGG ID D02709
MeSH ID C406224
PubChem ID 119607
TTD Drug ID D0L6DA
NDC Product Code Not Available
Synonyms valdecoxib | Bextra | SC 65872 | SC-65872
Chemical Information
Molecular Formula C16H14N2O3S
CAS Registry Number 181695-72-7
SMILES CC1=C(C(=NO1)C2=CC=CC=C2)C3=CC=C(C=C3)S(=O)(=O)N
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nuchal rigidity17.05.02.006; 15.05.04.005--Not Available
Dermatitis psoriasiform23.03.14.004--Not Available
Blood alkaline phosphatase increased13.04.02.004--
Hot flush24.03.01.005; 21.02.02.001; 08.01.03.027--
Prostate cancer21.04.02.002; 16.25.01.001--Not Available
Benign neoplasm16.02.02.007--Not Available
Embolism24.01.01.009--
Cardiac valve disease02.07.02.001--Not Available
Decreased appetite14.03.01.005; 08.01.09.028--
Erectile dysfunction21.03.01.007; 19.08.04.001--
Ill-defined disorder08.01.03.049--Not Available
Autonomic neuropathy17.05.01.009--Not Available
Psychotic disorder19.03.01.002--
Hyperlipidaemia14.08.03.001--
Soft tissue infection15.03.03.011; 11.01.17.006--
Cystitis noninfective20.03.02.001--
Breath sounds abnormal13.15.01.008--Not Available
Anorectal discomfort07.03.03.003--Not Available
Acute kidney injury20.01.03.016--
Candida infection11.03.03.021--
Anal incontinence17.05.01.021; 07.01.06.029--
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