| Pharmaceutical Information |
| Drug Name |
Urofollitropin |
| Drug ID |
BADD_D02319 |
| Description |
Urofollitropin is a urinary-derived follicle-stimulating hormone (FSH) that is extracted and purified from human urine samples. It consists of two non-covalently linked, non-identical glycoproteins designated as the alpha- and beta- subunits. The alpha- and beta- subunits have 92 and 111 amino acids. The alpha subunit is glycosylated at Asn 51 and Asn 78 while the beta subunit is glycosylated at Asn 7 and Asn 24. Urofollitropin is typically used injected subcutaneously in combination with human chorionic gonadotropin (hCG) to induce ovulation. Urofollitropin may also be used to cause the ovary to produce several follicles, which can then be harvested for use in gamete intrafallopian transfer (GIFT) or in vitro fertilization (IVF). |
| Indications and Usage |
For treatment of female infertility |
| Marketing Status |
approved; vet_approved |
| ATC Code |
G03GA04 |
| DrugBank ID |
DB00094
|
| KEGG ID |
D06269
|
| MeSH ID |
D050477
|
| PubChem ID |
62819
|
| TTD Drug ID |
D02SBQ
|
| NDC Product Code |
76403-5002; 71052-066; 76403-5001 |
| UNII |
W9BB98U6HP
|
| Synonyms |
Urofollitropin | Follicle-Stimulating Hormone, Human Urine | Follicle Stimulating Hormone, Human Urine | Human FSH, Urinary | Urinary Human FSH | Fertinex | Metrodin | Neo Fertinorm | Metrodin HP | Metrodin High Purity | High Purity, Metrodin | Bravelle | Follitrin |
|
| Chemical Information |
| Molecular Formula |
C42H65N11O12S2 |
| CAS Registry Number |
26995-91-5 |
| SMILES |
CCC(C)C1C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(C(=O)NC(C(=O)N1)CC2=CC=C(C=C2)O)N)C(=O)N3C
CCC3C(=O)NC(CC(C)C)C(=O)NCC(=O)N)CC(=O)N)C(C)O |
| Chemical Structure |
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| ADRs Induced by Drug |
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