Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Trospium
Drug ID BADD_D02305
Description Trospium is an antispasmodic agent used to treat the symptoms of overactive bladder, a condition that causes the bladder muscles to contract uncontrollably.[L6208] An overactive bladder leads to an increased urge to urinate, frequent urination, and sometimes, loss of control over urination.[L6208] Trospium is manufactured by _Indevus Pharmaceutical Inc._ and was granted FDA approval in 2007.[L6211]
Indications and Usage For the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency, detrusor instability and frequency of micturition.
Marketing Status Prescription; Discontinued
ATC Code G04BD09
DrugBank ID DB00209
KEGG ID D01103
MeSH ID C003330
PubChem ID 5284632
TTD Drug ID D05TIB
NDC Product Code Not Available
Synonyms trospium chloride | azoniaspiro compound XVII | azoniaspiro(3 alpha-benziloyloxynortropane-8,1'- pyrrolidine) chloride | Spasmex | Uraton | Spasmolyt | Spasmo-Urgenin TC | Spasmo-lyt | Spasmo-Rhoival TC | Trospi | Ceris | Uraplex | Spasmo-Urgenin
Chemical Information
Molecular Formula C25H30NO3+
CAS Registry Number 47608-32-2
SMILES C1CC[N+]2(C1)C3CCC2CC(C3)OC(=O)C(C4=CC=CC=C4)(C5=CC=CC=C5)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Eczema23.03.04.006--
Electrocardiogram abnormal13.14.05.001--Not Available
Endocrine disorder05.09.01.001--Not Available
Erythema multiforme23.03.01.003; 10.01.03.015--
Eye disorder06.08.03.001--Not Available
Eye pain06.08.03.002--
Faeces hard07.01.03.003--Not Available
Fatigue08.01.01.002--
Feeling abnormal08.01.09.014--Not Available
Flatulence07.01.04.002--
Fluid retention20.01.02.003; 14.05.06.002--Not Available
Flushing23.06.05.003; 24.03.01.002; 08.01.03.025--
Gastritis07.08.02.001--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Haematuria24.07.01.047; 20.02.01.006--
Hair growth abnormal23.02.06.006--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypertensive crisis24.08.01.001--Not Available
Hyperuricaemia14.09.01.003--
Infection11.01.08.002--Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Influenza like illness08.01.03.010--
Local swelling08.01.03.013--Not Available
Loss of consciousness17.02.04.004--Not Available
Lymphadenopathy01.09.01.002--Not Available
Menopausal symptoms21.02.02.002--Not Available
Micturition disorder20.02.02.005--Not Available
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