Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil sodium
Drug ID BADD_D02269
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status Prescription
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D08628
MeSH ID C427248
PubChem ID 23663413
TTD Drug ID D01WUA
NDC Product Code 54893-0022; 68245-0009; 40016-009; 82231-115; 58159-040; 14501-0016
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H33NaO5
CAS Registry Number 289480-64-4
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)[O-])O)O.[Na+]
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Bone pain15.02.01.001--
Cellulitis23.09.01.001; 11.02.01.001--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Diarrhoea07.02.01.001--
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dyspnoea22.02.01.004; 02.01.03.002--
Fatigue08.01.01.002--
Headache17.14.01.001--
Hypotension24.06.03.002--
Nausea07.01.07.001--
Oedema14.05.06.010; 08.01.07.006--Not Available
Pain in jaw15.02.01.003--Not Available
Pallor24.03.04.001; 23.03.03.031; 08.01.03.032--Not Available
Pruritus23.03.12.001--
Rash23.03.13.001--Not Available
Rash papular23.03.13.017--Not Available
Right ventricular failure02.05.03.002--Not Available
Thrombocytopenia01.08.01.002--Not Available
Thrombophlebitis24.01.02.001--Not Available
Vasodilatation24.03.02.003; 23.06.05.006--Not Available
Infusion related reaction12.02.05.009; 10.01.01.017; 08.01.03.002--
Infusion site pain12.07.05.002; 08.02.05.014--Not Available
Infusion site reaction12.07.05.006; 08.02.05.005--Not Available
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