Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status approved; investigational
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 0781-3430; 11014-0094; 66302-350; 66302-648; 66302-748; 66302-361; 66302-363; 66302-620; 66302-720; 0703-0676; 43598-646; 43598-647; 66302-302; 66302-325; 66302-616; 66302-362; 0703-0666; 14501-0015; 42023-209; 62332-515; 66302-110; 66302-300; 66302-610; 54893-0024; 43598-649; 62332-514; 62332-517; 66302-102; 66302-206; 66302-732; 58159-041; 68245-0008; 43598-648; 66302-120; 66302-600; 66302-650; 66302-764; 0703-0686; 0781-3420; 0781-3425; 81861-0029; 66302-101; 66302-310; 66302-630; 66302-664; 0781-3427; 42023-206; 66302-105; 66302-640; 42023-207; 62332-516; 66302-632; 66302-716; 42023-208
UNII RUM6K67ESG
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Intra-abdominal haemorrhage12.01.17.011; 24.07.02.035; 07.12.02.0080.000082%
Malnutrition14.03.02.0040.000123%Not Available
Cardiac valve disease02.07.02.0010.000082%Not Available
Decreased appetite08.01.09.028; 14.03.01.0050.010700%
Feeling of body temperature change08.01.09.0120.000280%Not Available
Pseudomonas infection11.02.12.001--Not Available
Ill-defined disorder08.01.03.049--Not Available
Blood disorder01.05.01.0040.000082%Not Available
Adjustment disorder19.23.01.0010.000082%Not Available
Autoimmune disorder10.04.04.0030.000123%
Disease progression08.01.03.0380.004532%
Drug intolerance08.06.01.0130.009927%Not Available
Obstructive airways disorder22.03.01.0110.000222%Not Available
Sinus disorder22.04.06.0020.000559%
Poor quality sleep19.02.05.005; 17.15.04.0020.000740%Not Available
Arterial occlusive disease24.04.02.0210.000082%Not Available
Infusion site extravasation12.07.05.008; 08.02.05.0070.001464%
Pulmonary arterial hypertension22.06.01.002; 24.08.03.0030.012271%Not Available
Infusion site haematoma24.07.01.042; 12.07.05.001; 08.02.05.0010.000123%Not Available
Infusion site haemorrhage12.07.05.018; 08.02.05.018; 24.07.01.0580.002591%Not Available
Infusion site irritation12.07.05.011; 08.02.05.0100.001143%Not Available
Infusion site urticaria23.04.02.010; 12.07.05.021; 10.01.06.010; 08.02.05.0210.000280%Not Available
Haematological malignancy16.21.01.002; 01.13.01.0030.000082%Not Available
Brain injury19.07.03.007; 17.11.01.0030.000164%Not Available
Oropharyngeal discomfort22.12.03.015; 07.05.05.0080.000181%Not Available
Oropharyngeal pain22.12.03.016; 07.05.05.0040.005963%
Acute kidney injury20.01.03.016--
Upper-airway cough syndrome22.12.03.0360.000280%
Functional gastrointestinal disorder07.11.01.0160.000222%Not Available
Catheter site extravasation12.07.02.012; 08.02.02.0120.000280%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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