Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Treprostinil
Drug ID BADD_D02268
Description Treprostinil is a synthetic analogue of prostacyclin, used to treat pulmonary hypertension.
Indications and Usage For use as a continuous subcutaneous infusion or intravenous infusion (for those not able to tolerate a subcutaneous infusion) for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise.
Marketing Status approved; investigational
ATC Code B01AC21
DrugBank ID DB00374
KEGG ID D06213
MeSH ID C427248
PubChem ID 6918140
TTD Drug ID D01WUA
NDC Product Code 0703-0696; 0781-3430; 11014-0094; 66302-350; 66302-648; 66302-748; 66302-361; 66302-363; 66302-620; 66302-720; 0703-0676; 43598-646; 43598-647; 66302-302; 66302-325; 66302-616; 66302-362; 0703-0666; 14501-0015; 42023-209; 62332-515; 66302-110; 66302-300; 66302-610; 54893-0024; 43598-649; 62332-514; 62332-517; 66302-102; 66302-206; 66302-732; 58159-041; 68245-0008; 43598-648; 66302-120; 66302-600; 66302-650; 66302-764; 0703-0686; 0781-3420; 0781-3425; 81861-0029; 66302-101; 66302-310; 66302-630; 66302-664; 0781-3427; 42023-206; 66302-105; 66302-640; 42023-207; 62332-516; 66302-632; 66302-716; 42023-208
UNII RUM6K67ESG
Synonyms treprostinil | ((1R,2R,3AS,9AS)-2-hydroxy-1-((3S)-3-hydroxyoctyl)-2,3,3A,4,9,9A-hexahydro-1H-cylopent(b)naphthalen-5-yl)oxy)acetate | treprostinil sodium | trepostinil sodium | Orenitram | UT-15 | UT-15C | Remodulin | treprostinil diolamine | treprostinil diolamin | treprostinil diethanolamine
Chemical Information
Molecular Formula C23H34O5
CAS Registry Number 81846-19-7
SMILES CCCCCC(CCC1C(CC2C1CC3=C(C2)C(=CC=C3)OCC(=O)O)O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Ventricular arrhythmia02.03.04.0060.000082%
Viral infection11.05.04.001--Not Available
Vomiting07.01.07.0030.018242%
Vomiting projectile07.01.07.0120.000280%Not Available
Wheezing22.03.01.0090.001867%
Withdrawal hypertension24.08.02.009; 08.06.02.0070.000082%Not Available
Mental status changes19.07.01.0010.000864%Not Available
Mobility decreased15.03.05.023; 17.02.05.018; 08.01.03.0300.001086%Not Available
Fibromyalgia15.05.02.0020.000280%Not Available
Infusion site erythema23.03.06.016; 12.07.05.009; 08.02.05.0080.009343%Not Available
Seasonal allergy22.04.04.008; 10.01.04.001; 06.04.01.0130.001439%Not Available
Peripheral swelling02.05.04.015; 08.01.03.0530.006456%Not Available
Localised oedema02.05.04.006; 14.05.06.009; 08.01.07.0110.000666%
Weight fluctuation14.03.02.0020.000321%Not Available
Brain death17.02.03.003; 08.04.01.0040.000164%Not Available
Sudden cardiac death08.04.01.008; 02.03.04.0160.000206%Not Available
General physical health deterioration08.01.03.0180.004096%Not Available
Left ventricular hypertrophy02.04.02.0140.000181%Not Available
Muscle tightness15.05.03.0070.000559%Not Available
Dysstasia15.03.05.011; 08.01.03.089; 17.02.02.0120.000502%Not Available
Contusion24.07.06.001; 23.03.11.002; 12.01.06.001; 15.03.05.007--
Musculoskeletal chest pain22.09.01.001; 15.03.04.0120.000263%
Cardiopulmonary failure22.02.06.004; 02.05.01.0040.000164%Not Available
Catheter site haemorrhage24.07.01.003; 12.07.02.002; 08.02.02.0020.000724%Not Available
Exercise tolerance decreased08.01.03.0360.000765%Not Available
Haemodynamic instability24.03.02.0060.000345%Not Available
Ear discomfort04.03.01.0050.000263%Not Available
Ocular discomfort06.08.03.0080.000419%Not Available
Respiratory tract congestion22.02.07.0030.001949%Not Available
Catheter site erythema23.03.06.014; 12.07.02.003; 08.02.02.0030.000362%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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