Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Trazodone hydrochloride
Drug ID BADD_D02267
Description Trazodone is triazolopyridine derivative from the serotonin receptor antagonists and reuptake inhibitors (SARIs) class of antidepressants.[A181180] It is used in adults and has been shown to be comparable in efficacy to other drugs such as tricyclic antidepressants (TCAs), selective serotonin reuptake inhibitors (SSRIs), and serotonin-norepinephrine receptor inhibitor (SNRIs) in the treatment of depression.[T646] A unique feature of this drug is that it does not promote the anxiety symptoms, sexual symptoms, or insomnia, which are commonly associated with SSRI and SNRI therapy.[T646] Trazodone acts on various receptors, including certain histamine, serotonin, and adrenergic receptors, distinguishing it from other antidepressants that cover a narrow range of neurotransmitters.[T646] It was initially granted FDA approval in 1981.[L3484]
Indications and Usage For the treatment of depression.
Marketing Status Prescription; Discontinued
ATC Code N06AX05
DrugBank ID DB00656
KEGG ID D00820
MeSH ID D014196
PubChem ID 62935
TTD Drug ID D00USF
NDC Product Code 55154-8087; 71205-568; 70771-1129; 70518-1489; 0555-0733; 0555-0711; 53489-510; 13107-081; 71205-551; 55700-844; 71610-537; 50090-4281; 70518-2973; 68071-4312; 71610-514; 71610-295; 68382-808; 55700-957; 53489-511; 55154-8085; 55700-855; 68382-805; 61919-585; 72789-154; 67296-1693; 68788-7166; 71610-529; 55700-921; 60505-2655; 46014-1118; 13107-082; 63629-3210; 65015-602; 50090-4819; 16729-299; 70518-2180; 0904-6869; 0615-8386; 13668-330; 70771-1130; 70518-1499; 42291-834; 38779-0559; 71335-0705; 58118-0429; 0615-8339; 50090-1561; 60760-806; 71335-0730; 71335-0035; 61919-473; 53002-3132; 70771-1128; 13668-332; 50268-776; 60687-443; 42291-868; 16729-301; 53002-2132; 0615-2579; 60505-2653; 61919-631; 60687-454; 70934-153; 71610-511; 61919-232; 70771-1131; 71205-630; 50111-433; 71610-525; 63187-680; 55700-810; 68071-4761; 71335-1630; 70518-2929; 67296-1411; 71205-574; 70518-0571; 50090-2373; 70518-1204; 70518-0847; 70934-817; 61919-231; 50090-5218; 60505-2659; 50090-4820; 0904-6868; 72789-168; 45865-431; 13107-080; 0615-2578; 68071-5187; 70934-818; 60505-2654; 63629-7287; 61919-386; 71610-513; 68071-4833; 13668-331; 70518-3082; 71610-530; 55700-739; 70518-3290; 50111-450; 50090-4402; 49452-7073; 68382-807; 58159-072; 50090-2372; 50111-434; 70518-3403; 50090-2462; 42291-829; 24823-911; 63629-8139; 42291-869; 61919-613; 53002-1105; 50090-2374; 50090-4283; 0904-6555; 43353-973; 63187-133; 53489-517; 65085-0014; 63187-377; 71335-1575; 0615-8371; 53002-1132; 50111-560; 13107-079; 55289-223; 68382-806; 43353-974; 0904-6554; 16729-300; 71335-1483; 55289-064; 60505-4089; 70934-119; 51927-0215; 70518-2793; 70518-1441; 71335-0742; 53002-4105; 60687-432; 71205-505; 42291-833; 50090-4825; 68788-7137; 16729-302; 50111-561; 13668-333; 63187-086; 68788-7118; 17511-116; 50090-0463; 68071-4410; 72789-079
Synonyms Trazodone | Tradozone | AF-1161 | AF 1161 | AF1161 | Deprax | Desyrel | Gen-Trazodone | Gen Trazodone | Molipaxin | Novo-Trazodone | Novo Trazodone | Trittico | PMS-Trazodone | PMS Trazodone | Ratio-Trazodone | Ratio Trazodone | RatioTrazodone | Thombran | Trazodon Hexal | Trazodon-Neuraxpharm | Trazodon Neuraxpharm | TrazodonNeuraxpharm | Trazodone Hydrochloride | Trazon | Apo-Trazodone | Apo Trazodone | Nu-Trazodone | Nu Trazodone
Chemical Information
Molecular Formula C19H23Cl2N5O
CAS Registry Number 25332-39-2
SMILES C1CN(CCN1CCCN2C(=O)N3C=CC=CC3=N2)C4=CC(=CC=C4)Cl.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Poisoning and toxicityCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abnormal dreams17.15.02.001; 19.02.03.001--Not Available
Agitation19.06.02.001; 17.02.05.012--
Akathisia19.06.02.006; 17.01.02.002--
Alopecia23.02.02.001--
Amenorrhoea21.01.02.001; 05.05.01.002--
Amylase increased13.05.01.009--
Anaemia01.03.02.001--
Anger19.04.02.001--Not Available
Anxiety19.06.02.002--
Aphasia19.21.01.001; 17.02.03.001--
Apnoea22.02.01.001--
Arrhythmia02.03.02.001--Not Available
Asthenia08.01.01.001--Not Available
Asthenopia06.01.01.002--Not Available
Ataxia17.02.02.001; 08.01.02.004--
Atrial fibrillation02.03.03.002--
Atrioventricular block02.03.01.002--Not Available
Bradycardia02.03.02.002--Not Available
Breast engorgement18.08.02.001; 21.05.05.002--Not Available
Breast enlargement21.05.04.001--Not Available
Cardiac arrest02.03.04.001--
Cardiac failure congestive02.05.01.002--Not Available
Cardiospasm07.02.04.007--Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills15.05.03.016; 08.01.09.001--
Cholestasis09.01.01.001--Not Available
Conduction disorder02.03.01.008--
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
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