| Drug Name |
Trastuzumab |
| Drug ID |
BADD_D02264 |
| Description |
Produced in CHO cell cultures, trastuzumab is a recombinant IgG1 kappa, humanized monoclonal antibody [A40276] that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein (HER2).[L14015] It is used as a treatment of human epidermal growth factor receptor (HER)-2+ metastatic breast cancer, where there is a proven amplification of the HER-2 oncogene or over-expression of the HER-2 protein in tumours. It is suggested that the overexpression or gene amplification of HER2 has been found in about 20–30% of breast cancers and elevated activation of HER2 triggers multiple downstream pathways leading to abnormal proliferation of cancer cells [A121]. Trastuzumab binds to HER2 and suppresses cancer cells growth, proliferation, and survival directly and indirectly [A121].
In December 2017, FDA approved Ogivri (trastuzumab-dkst) as a biosimilar to Herceptin (trastuzumab) for the treatment of patients with breast or metastatic stomach cancer (gastric or gastroesophageal junction adenocarcinoma) whose tumors overexpress the HER2 gene (HER2+). It displays biosimilar properties as Herceptin according to clinical data. While Ogivri is the first biosimilar approved in the U.S. for the treatment of breast cancer or stomach cancer, it is the second biosimilar approved in the U.S. for the treatment of cancer. Herzuma (trastuzumab-pkrb) is a biosimilar drug approved in December 2018 for the treatment of HER2-overexpressing breast cancer. KANJINTI (trastuzumab-anns) is another biosimilar approved by the FDA in June 2019.[L14135] |
| Indications and Usage |
For treatment of early stage HER2-positive breast cancer, or metastatic breast cancer that substantially overexpress HER2. |
| Marketing Status |
Prescription |
| ATC Code |
L01FD01 |
| DrugBank ID |
DB00072
|
| KEGG ID |
D03257
|
| MeSH ID |
D000068878
|
| PubChem ID |
Not Available
|
| TTD Drug ID |
D04WFL
|
| NDC Product Code |
68225-106; 67643-0010; 63552-037; 69438-0002; 50242-133; 67457-847; 67457-991; 78848-007; 63459-305; 63459-303; 67457-845; 78206-147; 0006-5033; 50242-132; 78848-006 |
| Synonyms |
Trastuzumab | Trastuzumab beta | beta, Trastuzumab | Herceptin | Trazimera | Trastuzumab-qyyp | Trastuzumab qyyp |
