Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tranylcypromine
Drug ID BADD_D02262
Description A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders (From AMA Drug Evaluations Annual, 1994, p311). Tranylcypromine is a racemate comprising equal amounts of (1R,2S)- and (1S,2R)-2-phenylcyclopropan-1-amine with the chiral centers both located on the cylopropane ring. An irreversible monoamine oxidase inhibitor that is used as an antidepressant (INN tranylcypromine).
Indications and Usage For the treatment of major depressive episode without melancholia.
Marketing Status Prescription
ATC Code N06AF04
DrugBank ID DB00752
KEGG ID D08625
MeSH ID D014191
PubChem ID 5530
TTD Drug ID D0H0HJ
NDC Product Code 70954-538
Synonyms Tranylcypromine | trans-2-Phenylcyclopropylamine | trans 2 Phenylcyclopropylamine | Tranylcypromine Sulfate | Sulfate, Tranylcypromine | Jatrosom | Transamine | Parnate
Chemical Information
Molecular Formula C9H11N
CAS Registry Number 155-09-9
SMILES C1C(C1N)C2=CC=CC=C2
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Metabolic disorderActivity-regulated cytoskeleton-associated proteinQ9WV31Not Available14580947; 15838995; 15087240
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Acne cystic23.02.01.005--Not Available
Agranulocytosis01.02.03.001--Not Available
Akinesia17.01.02.003--Not Available
Alopecia23.02.02.001--
Amnesia19.20.01.001; 17.03.02.001--
Anaemia01.03.02.001--
Anxiety19.06.02.002--
Asthenia08.01.01.001--Not Available
Ataxia08.01.02.004; 17.02.02.001--
Blood pressure increased13.14.03.005--Not Available
Chills15.05.03.016; 08.01.09.001--
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Dermatitis23.03.04.002--Not Available
Diarrhoea07.02.01.001--
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry mouth07.06.01.002--
Feeling abnormal08.01.09.014--Not Available
Gastrointestinal pain07.01.05.005--
Headache17.14.01.001--
Hepatitis09.01.07.004--Not Available
Hypoaesthesia17.02.06.023--Not Available
Insomnia19.02.01.002; 17.15.03.002--
Leukopenia01.02.02.001--Not Available
Morphoea15.06.01.008; 10.04.07.002; 23.03.02.011--Not Available
Muscle spasms15.05.03.004--
Myoclonus17.02.05.008--Not Available
Nausea07.01.07.001--
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