Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tranexamic acid
Drug ID BADD_D02261
Description Tranexamic acid is a synthetic derivative of [lysine] used as an antifibrinolytic in the treatment and prevention of major bleeding. It possesses a similar mechanism of action to [aminocaproic acid] but is approximately 10-fold more potent.[L31883] It was first patented in 1957[A230108] and received its initial US approval in 1986.[L31858]
Indications and Usage Dunn CJ, Goa KL: Tranexamic acid: a review of its use in surgery and other indications. Drugs. 1999 Jun;57(6):1005-32.
Marketing Status Prescription; Discontinued
ATC Code B02AA02
DrugBank ID DB00302
KEGG ID D01136
MeSH ID D014148
PubChem ID 5526
TTD Drug ID D05HXX
NDC Product Code 12079-2001; 71052-166; 42571-314; 51754-0108; 67457-197; 71335-1957; 69918-301; 60505-6169; 70860-400; 0591-3720; 63629-8838; 67850-041; 50090-5072; 0013-1114; 51552-0513; 38779-3211; 42571-189; 49452-7877; 67850-042; 81999-0001; 43066-008; 72485-107; 68382-891; 39822-1000; 55150-188; 72611-760; 50090-4530; 49452-7876; 12848-1004; 71335-1981; 70121-1398; 51662-1532; 65388-0156; 61990-0611; 63323-563; 65145-106; 23155-166; 38779-2794; 81284-611; 70771-1085; 73309-178; 57218-951; 63629-8599; 51927-0022; 63759-0038; 62991-3131; 69918-300; 17478-017; 0517-0960; 81284-612; 17478-018; 62559-265; 68083-160; 55566-2110; 23155-524
Synonyms Tranexamic Acid | AMCHA | trans-4-(Aminomethyl)cyclohexanecarboxylic Acid | t-AMCHA | AMCA | Anvitoff | Cyklokapron | Ugurol | KABI 2161 | Spotof | Transamin | Amchafibrin | Exacyl
Chemical Information
Molecular Formula C8H15NO2
CAS Registry Number 701-54-2
SMILES C1CC(CCC1CN)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal discomfort07.01.06.001--Not Available
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Abdominal tenderness07.01.05.004--Not Available
Acute myocardial infarction24.04.04.001; 02.02.02.0010.057154%Not Available
Acute sinusitis22.07.03.013; 11.01.13.012--Not Available
Agitation19.06.02.001; 17.02.05.012--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.0010.064298%
Anaphylactic shock24.06.02.004; 10.01.07.0020.014288%Not Available
Anaphylactoid reaction10.01.07.003; 24.06.03.007--Not Available
Aneurysm24.02.01.001--Not Available
Angina pectoris24.04.04.002; 02.02.02.002--
Anxiety19.06.02.002--
Aortic dissection24.02.03.002--Not Available
Aphasia19.21.01.001; 17.02.03.0010.014288%
Arrhythmia02.03.02.0010.035721%Not Available
Arterial thrombosis24.01.01.0020.028577%Not Available
Arthralgia15.01.02.0010.035721%
Asthenia08.01.01.001--Not Available
Atrial fibrillation02.03.03.0020.128596%
Atrioventricular block02.03.01.002--Not Available
Atrioventricular block complete02.03.01.0030.014288%
Back pain15.03.04.0050.057154%
Blindness unilateral17.17.01.016; 06.02.02.0090.014288%Not Available
Blood pressure abnormal13.14.03.0010.021433%Not Available
Blood pressure decreased13.14.03.0020.021433%Not Available
Blood pressure increased13.14.03.005--Not Available
Bronchospasm22.03.01.004; 10.01.03.0120.005591%
Cardiac arrest02.03.04.0010.027956%
The 1th Page    1 2 3 4 5    Next   Last    Total 7 Pages