Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tositumomab
Drug ID BADD_D02252
Description Murine IgG2a lambda monoclonal antibody against CD20 antigen (2 heavy chains of 451 residues, 2 lambda chains of 220 residues). It is produced in an antibiotic-free culture of mammalian cells. It can be covalently linked to Iodine 131 (a radioactive isotope of iodine).
Indications and Usage For treatment of non-Hodgkin's lymphoma (CD20 positive, follicular)
Marketing Status Not Available
ATC Code V10XA53
DrugBank ID DB00081
KEGG ID D08622
MeSH ID C119496
PubChem ID Not Available
TTD Drug ID D0I2AV
NDC Product Code Not Available
Synonyms tositumomab I-131 | 131I-tositumomab | anti-B1 antibody I-131 | tositumomab conjugate with 131I | iodine (131I) tositumomab | iodine-131 tositumomab | I-131 anti-B1 antibody | iodine-131 anti-B1 monoclonal antibody | iodine-131-labeled anti-CD20 antibody | iodine-131-tositumomab | tositumomab iodine-131 | iodine-131 anti-B1 antibody | 131I anti-B1 | Bexxar
Chemical Information
Molecular Formula Not Available
CAS Registry Number 208921-02-2
SMILES Not Available
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Anaemia01.03.02.001--
Anaphylactic reaction24.06.03.006; 10.01.07.001--
Angioedema23.04.01.001; 10.01.05.009--Not Available
Arthralgia15.01.02.001--
Asthenia08.01.01.001--Not Available
Back pain15.03.04.005--
Bacteraemia11.01.11.001--
Bladder cancer20.03.04.001; 16.08.01.001--Not Available
Blood thyroid stimulating hormone increased13.10.03.006--
Breast cancer21.05.01.003; 16.10.01.001--Not Available
Bronchitis22.07.01.001; 11.01.09.001--
Bronchospasm22.03.01.004; 10.01.03.012--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Chills08.01.09.001; 15.05.03.016--
Constipation07.02.02.001--
Cough22.02.03.001--
Dehydration14.05.05.001--
Diarrhoea07.02.01.001--
Dizziness17.02.05.003; 24.06.02.007; 02.01.02.004--
Dyspepsia07.01.02.001--
Dyspnoea02.01.03.002; 22.02.01.004--
Face oedema23.04.01.004; 10.01.05.002; 08.01.07.003--
Gastric cancer16.13.03.001; 07.21.02.001--Not Available
Headache17.14.01.001--
Hyperhidrosis08.01.03.028; 23.02.03.004--
Hypersensitivity10.01.03.003--
Hypotension24.06.03.002--
Hypothyroidism14.11.01.012; 05.02.03.001--
Infection11.01.08.002--Not Available
The 1th Page    1 2 3    Next   Last    Total 3 Pages