Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tolazoline hydrochloride
Drug ID BADD_D02239
Description A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
Indications and Usage For the treatment of pulmonary artery anomalies
Marketing Status Discontinued
ATC Code C04AB02; M02AX02
DrugBank ID DB00797
KEGG ID D00997
MeSH ID D014043
PubChem ID 6048
TTD Drug ID D03RZV
NDC Product Code 49452-7831
Synonyms Tolazoline | Benzalolin | Priscoline | Priscol | Tolazoline Hydrochloride | Tolazoline Monohydrochloride | Divascol | Pridazole
Chemical Information
Molecular Formula C10H13ClN2
CAS Registry Number 59-97-2
SMILES C1CN=C(N1)CC2=CC=CC=C2.Cl
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Arrhythmia02.03.02.001--Not Available
Diarrhoea07.02.01.001--
Feeling cold08.01.09.008--Not Available
Flushing24.03.01.002; 23.06.05.003; 08.01.03.025--
Gastrointestinal haemorrhage24.07.02.009; 07.12.02.001--Not Available
Haematuria24.07.01.047; 20.02.01.006--
Hepatitis09.01.07.004--Not Available
Hypertension24.08.02.001--
Hypotension24.06.03.002--
Leukopenia01.02.02.001--Not Available
Nausea07.01.07.001--
Oedema14.05.06.010; 08.01.07.006--Not Available
Oliguria20.01.03.004--Not Available
Paraesthesia17.02.06.005--
Pulmonary haemorrhage24.07.01.016; 22.02.04.003--
Rash23.03.13.001--Not Available
Tachycardia02.03.02.007--Not Available
Thrombocytopenia01.08.01.002--Not Available
Vomiting07.01.07.003--
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