Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tiotropium bromide
Drug ID BADD_D02224
Description Tiotropium is a long-acting, antimuscarinic bronchodilator used in the management of chronic obstructive pulmonary disease (COPD) and asthma.[A180163,L7084,L7087,L7090,L7093] Tiotropium acts mainly on M3 muscarinic receptors located in the airways to produce smooth muscle relaxation and bronchodilation.[A180163,L7084,L7087,L7090,L7093] Tiotropium is more specific for the subset of muscarinic receptors commonly found in the lungs than [ipratropium].[A180163] Tiotropium was granted FDA approval on 30 January 2004.[L7084]
Indications and Usage Tiotropium powder for inhalation is indicated for the maintenance of bronchospasm in COPD and to prevent exacerbations of COPD.[L7084] A combination tiotropium and [olodaterol] metered inhalation spray is indicated for maintenance of COPD.[L7087] A tiotropium inhalation spray is indicated for the maintenance of bronchospasm in COPD, to prevent exacerbations of COPD, and to treat asthma in patients 12 or more years old.[L7090] A tiotropium metered inhalation spray is indicated for the maintenance of bronchospasm in COPD, to prevent exacerbations of COPD, and to treat asthma in patients 6 or more years old.[L7093]
Marketing Status approved
ATC Code R03BB04
DrugBank ID DB01409
KEGG ID D01929
MeSH ID D000069447
PubChem ID 5487426
NDC Product Code 0597-0075; 58175-0565; 50090-4248; 68180-964; 54239-011
UNII 0EB439235F
Synonyms Tiotropium Bromide | Bromide, Tiotropium | 7-((hydroxybis(2-thienyl)acetyl)oxy)-9,9-dimethyl-3-oxa-9-azoniatricyclo(,4))nonane bromide | Tiotropium | Spiriva | BA 679 BR | 679 BR, BA | BR, BA 679 | BA-679 BR | BA679 BR
Chemical Information
Molecular Formula C19H22BrNO4S2
CAS Registry Number 136310-93-5
SMILES C[N+]1(C2CC(CC1C3C2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C.[Br-]
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Abdominal pain07.01.05.002--
Abdominal pain upper07.01.05.003--
Accident12.01.08.001--Not Available
Aneurysm24.02.01.001--Not Available
Angina pectoris02.02.02.002;
Angioedema22.04.02.008;; Available
Angle closure glaucoma06.03.01.001--Not Available
Application site irritation12.07.01.003; Available
Arrhythmia02.03.02.001--Not Available
Atrial fibrillation02.03.03.002--
Back pain15.03.04.005--
Benign prostatic hyperplasia21.04.02.001--Not Available
Bladder neck obstruction20.03.01.010--Not Available
Bone pain15.02.01.001--
Bronchospasm paradoxical22.03.01.006--Not Available
Chest pain22.12.02.003;; Available
Dermatitis23.03.04.002--Not Available
Dry mouth07.06.01.002--
Dry skin23.03.03.001--
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