Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Timolol maleate
Drug ID BADD_D02220
Description Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes.[L6724] It is also used in tablet form as a drug to treat hypertension.[L6727] Timolol was first approved by the FDA in 1978.[L6724] This drug is marketed by several manufacturers [L6736] and is an effective agent for the management of conditions such as open-angle glaucoma and hypertension.
Indications and Usage In its oral form it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its opthalmic form it is used to treat open-angle and occasionally secondary glaucoma.
Marketing Status Prescription; Discontinued
ATC Code C07AA06; S01ED01
DrugBank ID DB00373
KEGG ID D00603
MeSH ID D013999
PubChem ID 5281056
TTD Drug ID D05UVD
NDC Product Code 54871-1088; 70447-0002; 64980-514; 0378-0221; 24208-816; 51014-7510; 0378-0055; 50090-0558; 67877-229; 60758-801; 55545-0440; 45865-121; 0378-0715; 24208-813; 60758-802; 24208-812; 49452-7813; 24208-499; 50090-3441; 61314-226; 61314-225; 17478-289; 50090-5091; 73152-030; 61314-224; 24208-814; 51927-2003; 50090-5769; 63629-7167; 69918-602; 24208-818; 50383-021; 73152-031; 13811-618; 24208-004; 64980-513; 17478-288; 11722-076; 38779-0366; 68682-813; 0187-1498; 61314-227; 69918-601; 24208-496; 17337-0543; 64330-014; 24208-819; 52423-0913; 82260-496; 46014-1059; 60505-1005; 73152-029; 68682-045; 24208-498; 0187-1496; 68682-812
Synonyms Timolol | Timolol Maleate | Timolol Maleate, (1:1) Salt | (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol | 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)- | Timoptic | Timoptol | Timacar | Timolol Hemihydrate | Blocadren | L-714,465 | L 714,465 | L714,465 | MK-950 | MK 950 | MK950 | Optimol
Chemical Information
Molecular Formula C17H28N4O7S
CAS Registry Number 60469-65-0
SMILES CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O.C(=CC(=O)O)C(=O)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Dry eye06.08.02.001--
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.002--
Dysuria20.02.02.002--
Ear infection11.01.05.001; 04.03.01.006--Not Available
Eye irritation06.04.05.003--Not Available
Eyelid ptosis17.17.02.004; 06.05.01.002--Not Available
Fatigue08.01.01.002--
Gastrointestinal disorder07.11.01.001--Not Available
Gastrointestinal pain07.01.05.005--
Haematocrit13.01.05.017--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Hallucination19.10.02.002--
Headache17.14.01.001--
Heart rate decreased13.14.04.001--Not Available
Hepatomegaly09.01.05.001--Not Available
High density lipoprotein decreased13.12.01.003--Not Available
Hyperglycaemia14.06.02.002; 05.06.02.002--
Hyperhidrosis23.02.03.004; 08.01.03.028--
Hypoglycaemia05.06.03.001; 14.06.03.001--
Hypotension24.06.03.002--
Insomnia19.02.01.002; 17.15.03.002--
Intermittent claudication24.04.03.001--Not Available
Laryngospasm22.04.02.002--
Libido decreased21.03.02.005; 19.08.03.001--
Liver function test abnormal13.03.01.013--Not Available
Mesenteric artery thrombosis24.01.08.003; 07.15.02.008--Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Nausea07.01.07.001--
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