Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Timolol
Drug ID BADD_D02219
Description Timolol is a nonselective beta-adrenergic antagonist given in an eye drop solution to reduce intraocular pressure, or pressure in the eyes.[L6724] It is also used in tablet form as a drug to treat hypertension.[L6727] Timolol was first approved by the FDA in 1978.[L6724] This drug is marketed by several manufacturers [L6736] and is an effective agent for the management of conditions such as open-angle glaucoma and hypertension.
Indications and Usage In its oral form it is used to treat high blood pressure and prevent heart attacks, and occasionally to prevent migraine headaches. In its opthalmic form it is used to treat open-angle and occasionally secondary glaucoma.
Marketing Status Prescription; Discontinued
ATC Code C07AA06; S01ED01
DrugBank ID DB00373
KEGG ID D00378
MeSH ID D013999
PubChem ID 33624
TTD Drug ID D05UVD
NDC Product Code 17478-365; 76478-002; 17478-366; 76478-001; 17478-189
Synonyms Timolol | Timolol Maleate | Timolol Maleate, (1:1) Salt | (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol | 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)- | Timoptic | Timoptol | Timacar | Timolol Hemihydrate | Blocadren | L-714,465 | L 714,465 | L714,465 | MK-950 | MK 950 | MK950 | Optimol
Chemical Information
Molecular Formula C13H24N4O3S
CAS Registry Number 26839-75-8
SMILES CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Adverse drug reactionCytochrome P450 2D6P10635T57392Not Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cataract06.06.01.0010.001317%
Catatonia19.11.01.001--Not Available
Cerebral ischaemia24.04.06.003; 17.08.01.005--
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Cerebrovascular disorder17.08.02.002; 24.03.05.002--Not Available
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Choroidal detachment12.01.04.006; 06.09.01.003--Not Available
Colitis ischaemic24.04.08.012; 07.08.01.004--Not Available
Conduction disorder02.03.01.0080.000439%
Confusional state19.13.01.001; 17.02.03.005--
Conjunctival oedema06.04.01.0010.000439%Not Available
Conjunctivitis11.01.06.012; 06.04.01.002--
Coronary artery disease24.04.04.006; 02.02.01.001--Not Available
Cough22.02.03.001--
Death08.04.01.001--
Depression19.15.01.001--
Dermatitis23.03.04.002--Not Available
Dermatitis exfoliative23.03.07.001; 10.01.01.004--
Diarrhoea07.02.01.001--
Diplopia17.17.01.005; 06.02.06.0020.000439%Not Available
Discomfort08.01.08.003--Not Available
Disorientation19.13.01.002; 17.02.05.015--Not Available
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.0040.001097%
Drug hypersensitivity10.01.01.0010.001097%Not Available
Dry eye06.08.02.001--
Dry mouth07.06.01.002--
Dupuytren's contracture15.03.03.0030.000658%Not Available
Dysgeusia17.02.07.003; 07.14.03.0010.000439%
Dyspepsia07.01.02.001--
Dyspnoea22.02.01.004; 02.01.03.0020.000878%
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