ADReCS

Pharmaceutical Information

Drug Name	Ticagrelor
Drug ID	BADD_D02214
Description	Ticagrelor, or AZD6140, was first described in the literature in 2003.[A204170,A2903] Ticagrelor is an ADP derivative developed for its P2Y₁₂ receptor antagonism.[A2903] Unlike [clopidogrel], ticagrelor is not a prodrug.[A2903] It is marketed by Astra Zeneca as Brilinta in the US[L14201] and Brilique or Possia in the EU,[L14207]. Ticagrelor was granted EMA approval on 3 December 2010.[L14207] Ticagrelor was granted FDA approval on 20 July 2011.[L14201]
Indications and Usage	Ticagrelor is indicated to reduce the risk of cardiovascular death, myocardial infarction, and stroke in patients with acute coronary syndrome or a history of myocardial infarction.[L14201] Ticagrelor is also indicated to reduce the risk of a first myocardial infarction or stroke in high risk patients with coronary artery disease.[L14201]
Marketing Status	approved
ATC Code	B01AC24
DrugBank ID	DB08816
KEGG ID	D09017
MeSH ID	D000077486
PubChem ID	9871419
TTD Drug ID	D0WF7L
NDC Product Code	53747-092; 69037-0007; 76072-1016; 0186-0777; 45941-3055; 50379-0011; 50923-0314; 58623-0131; 69238-1134; 49587-109; 50379-0023; 55154-9618; 15894-0030; 83137-0001; 17228-0776; 49187-0205; 17228-0777; 17228-7777; 62147-0280; 82712-1001; 0186-0776; 55111-969; 65372-1198
UNII	GLH0314RVC
Synonyms	Ticagrelor \| Brilique \| AZD 6140 \| AZD6140 \| AZD-6140 \| Brilinta \| 3-(7-((2-(3,4-Difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-(1-3)-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

Chemical Information

Molecular Formula	C23H28F2N6O4S
CAS Registry Number	274693-27-5
SMILES	CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F
Chemical Structure

ADRs Induced by Drug

*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..

ADR Term	ADReCS ID	ADR Frequency (FAERS)	ADR Severity Grade (FAERS)	ADR Severity Grade (CTCAE)
Peripheral swelling	08.01.03.053; 02.05.04.015	-	-	Not Available
Brain oedema	17.07.02.003; 12.01.10.010	0.000272%
Spinal cord haemorrhage	24.07.04.010; 17.08.01.030; 12.01.13.003	-	-	Not Available
Brain death	17.02.03.003; 08.04.01.004	0.000544%		Not Available
Nocturnal dyspnoea	02.11.05.009; 22.02.01.019	0.000870%		Not Available
Sudden cardiac death	08.04.01.008; 02.03.04.016	0.000272%		Not Available
Left ventricular dysfunction	02.04.02.011	0.000272%
Bradyarrhythmia	02.03.02.015	0.000272%		Not Available
Shock haemorrhagic	24.06.02.014; 14.05.05.003	0.000680%		Not Available
Contusion	15.03.05.007; 24.07.06.001; 23.03.11.002; 12.01.06.001	-	-
Lower gastrointestinal haemorrhage	07.12.03.011; 24.07.02.030	0.000680%
Post procedural haemorrhage	24.07.01.014; 12.02.05.004	-	-
Catheter site haemorrhage	12.07.02.002; 24.07.01.003; 08.02.02.002	-	-	Not Available
Puncture site haemorrhage	12.07.04.006; 08.02.04.007; 24.07.01.034	-	-	Not Available
Exercise tolerance decreased	08.01.03.036	0.000925%		Not Available
Wound haemorrhage	24.07.01.029; 12.01.08.017	-	-	Not Available
Systemic inflammatory response syndrome	08.01.05.005; 24.06.03.008; 10.02.01.008	0.000272%		Not Available
Large intestine polyp	16.05.02.006; 07.20.01.010	0.000408%		Not Available
Acute coronary syndrome	24.04.04.011; 02.02.02.015	0.004487%		Not Available
Metabolic syndrome	14.06.02.007; 05.06.02.007; 24.08.02.014	0.000598%		Not Available
Haemodynamic instability	24.03.02.006	0.001088%		Not Available
Traumatic haemorrhage	24.07.01.056; 12.01.08.029	-	-	Not Available
Vascular occlusion	24.04.02.015	0.000952%		Not Available
Cerebral haematoma	24.07.04.006; 17.08.01.014	0.000272%		Not Available
Vessel puncture site haemorrhage	08.02.04.014; 24.07.01.061; 12.07.04.014	-	-	Not Available
Haemorrhoidal haemorrhage	24.10.02.001; 07.15.03.002	0.000272%
Haemorrhage	24.07.01.002	0.019554%		Not Available
Haemorrhage urinary tract	20.02.03.005; 24.07.01.007	-	-	Not Available
Gastrointestinal ulcer haemorrhage	24.07.02.023; 07.04.04.006	-	-	Not Available
Retroperitoneal haematoma	24.07.01.060; 07.07.02.005	0.000408%		Not Available

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