| Pharmaceutical Information |
| Drug Name |
Thrombin (human) |
| Drug ID |
BADD_D02205 |
| Description |
Human thrombin is a sterile solution, pH 6.8-7.2, containing highly purified human thrombin for the activation of clotting. Thrombin is a highly specific serine protease encoded by the F2 gene that transforms soluble fibrinogen into insoluble fibrin. This transformation mimics the final coagulation cascade step which involves the clotting mass that adheres to the wound surface and achieves hemostasis and sealing of open tissues.
In particular, while human thrombin products are made from pooled human source plasma, recombinant thrombin is a human coagulation protein produced via recombinant DNA technology from a genetically modified Chinese hamster ovary cell line [FDA Label]. Furthermore, human thrombin is manufactured by chromatographic purification of prothrombin from cryo-poor plasma followed by activation with calcium chloride [FDA Label]. |
| Indications and Usage |
|
| Marketing Status |
Not Available |
| ATC Code |
B02BC06; B02BD30 |
| DrugBank ID |
DB11571
|
| KEGG ID |
D00090
|
| MeSH ID |
D013917
|
| PubChem ID |
Not Available
|
| TTD Drug ID |
Not Available
|
| NDC Product Code |
63713-460; 68225-108 |
| Synonyms |
Thrombin | Thrombase | Thrombostat | alpha-Thrombin | Thrombin JMI | JMI, Thrombin | Thrombin-JMI | beta-Thrombin | gamma-Thrombin | Thrombinar | beta,gamma-Thrombin |
|
| Chemical Information |
| Molecular Formula |
Not Available |
| CAS Registry Number |
9002-04-4 |
| SMILES |
Not Available |
| Chemical Structure |
|
|
| ADR Related Proteins Induced by Drug |
| ADR Term |
Protein Name |
UniProt AC |
TTD Target ID |
PMID |
| Not Available | Not Available | Not Available | Not Available | Not Available |
|
| ADRs Induced by Drug |
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