Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Thiotepa
Drug ID BADD_D02203
Description N,N'N'-triethylenethiophosphoramide (ThioTEPA) is a cancer chemotherapeutic member of the alkylating agent group, now in use for over 50 years. It is a stable derivative of N,N',N''- triethylenephosphoramide (TEPA). It is mostly used to treat breast cancer, ovarian cancer and bladder cancer. It is also used as conditioning for Bone marrow transplantation. Its main toxicity is myelosuppression.
Indications and Usage ThioTEPA is used a as conditioning treatment prior to allogeneic or autologous haematopoietic progenitor cell transplantation (HPCT) in haematological diseases in adult and paediatric patients. Also, when high dose chemotherapy with HPCT support it is appropriate for the treatment of solid tumours in adult and paediatric patients.
Marketing Status Prescription; Discontinued
ATC Code L01AC01
DrugBank ID DB04572
KEGG ID D00583
MeSH ID D013852
PubChem ID 5453
TTD Drug ID D00YZA
NDC Product Code 54879-014; 70121-1631; 58621-004; 72205-045; 54875-0004; 72205-046; 0143-9309; 0143-9565; 70121-1630; 43598-650; 68083-503; 70225-1104; 65219-029; 69539-124; 69539-123; 68083-446; 54893-0045; 25021-246; 50683-0465
Synonyms Thiotepa | Thio-Tepa | Thio Tepa | Tris(1-aziridinyl)phosphine Sulfide | Thiophosphamide | Triethylenethiophosphoramide | Tespamin | NSC-6396 | NSC 6396 | NSC6396 | Tespa | AI3-24916 | AI3 24916 | AI324916 | Girostan
Chemical Information
Molecular Formula C6H12N3PS
CAS Registry Number 52-24-4
SMILES C1CN1P(=S)(N2CC2)N3CC3
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood electrolytes abnormal13.11.02.002--Not Available
Cardiac disorder02.01.01.003--Not Available
Connective tissue disorder15.06.01.006--Not Available
Embolism24.01.01.009--
Infestation23.09.05.001; 11.09.01.001--Not Available
Malnutrition14.03.02.004--Not Available
Mediastinal disorder22.09.03.001--Not Available
Mental disorder19.07.01.002--Not Available
Decreased appetite14.03.01.005; 08.01.09.0280.000533%
Gastrointestinal ulcer07.04.04.002--Not Available
Inner ear disorder04.04.02.002--Not Available
Polyp16.02.02.005; 08.01.06.010--Not Available
Blood disorder01.05.01.004--Not Available
Hepatobiliary disease09.01.08.003--Not Available
Pigmentation disorder23.05.03.001--Not Available
Venoocclusive disease24.03.02.0160.000139%Not Available
Cystitis noninfective20.03.02.001--
Idiopathic pneumonia syndrome22.01.02.015; 12.02.07.006--Not Available
Bone marrow failure01.03.03.0050.000799%
Cardiovascular insufficiency24.06.03.005; 02.01.01.011--Not Available
Acute graft versus host disease10.02.01.028; 12.02.09.002--Not Available
Chronic graft versus host disease12.02.09.003; 10.02.01.029--Not Available
Cytopenia01.03.03.012--Not Available
Multiple organ dysfunction syndrome08.01.03.057--
Clostridium difficile infection11.02.02.0090.000533%Not Available
Body height below normal13.15.01.0350.000799%Not Available
Central nervous system necrosis24.04.06.032; 17.02.10.0200.000278%
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