Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tetrabenazine
Drug ID BADD_D02175
Description A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
Indications and Usage Treatment of hyperkinetic movement disorders like chorea in Huntington's disease, hemiballismus, senile chorea, Tourette syndrome and other tic disorders, and tardive dyskinesia
Marketing Status Prescription
ATC Code N07XX06
DrugBank ID DB04844
KEGG ID D08575
MeSH ID D013747
PubChem ID 6018
TTD Drug ID D09PJX
NDC Product Code 0054-0469; 60505-3882; 51224-426; 43598-394; 27241-177; 42291-806; 51224-425; 65977-0085; 47335-277; 31722-822; 68180-408; 70436-102; 51407-481; 42291-807; 65085-0064; 65015-831; 0054-0468; 69452-117; 69766-076; 43598-395; 42973-179; 62756-871; 31722-821; 64330-066; 68180-409; 64567-0025; 68682-421; 63827-1013; 51407-480; 69452-118; 47335-179; 68682-422; 60505-3883; 70436-101; 27241-176
Synonyms Tetrabenazine | Nitoman | Xenazine
Chemical Information
Molecular Formula C19H27NO3
CAS Registry Number 718635-93-9
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nausea07.01.07.001--
Neoplasm malignant16.16.01.0010.001364%Not Available
Nervous system disorder17.02.10.001--Not Available
Nervousness19.06.02.0030.005229%Not Available
Neuroleptic malignant syndrome12.03.01.003; 08.05.01.005; 17.05.02.003; 15.05.04.0150.000682%Not Available
Obsessive-compulsive disorder19.06.05.002--Not Available
Oculogyric crisis17.01.03.002; 06.05.02.002--Not Available
Orthostatic hypotension24.06.03.004; 17.05.01.020--Not Available
Osteoarthritis15.01.04.001--Not Available
Pain08.01.08.004--
Pain in extremity15.03.04.010--
Paranoia19.05.01.0050.003921%Not Available
Parkinsonism17.01.05.0030.005229%Not Available
Photophobia17.17.02.006; 06.01.01.004--
Pneumonia22.07.01.003; 11.01.09.0030.019607%Not Available
Pneumonia aspiration22.01.01.0050.001364%Not Available
Pyrexia08.05.02.003--
Rash23.03.13.001--Not Available
Renal failure20.01.03.005--Not Available
Respiratory arrest22.02.01.0090.001023%Not Available
Respiratory disorder22.02.07.0020.002614%Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Restlessness19.11.02.002; 17.02.05.0210.006536%
Rhabdomyolysis15.05.05.0020.003921%
Salivary hypersecretion07.06.01.0090.005229%Not Available
Sedation17.02.04.0050.006536%Not Available
Seizure17.12.03.001--
Sepsis11.01.11.003--
Septic shock11.01.11.004; 24.06.02.0110.000682%Not Available
Skin disorder23.03.03.007--Not Available
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