Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tetrabenazine
Drug ID BADD_D02175
Description A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
Indications and Usage Treatment of hyperkinetic movement disorders like chorea in Huntington's disease, hemiballismus, senile chorea, Tourette syndrome and other tic disorders, and tardive dyskinesia
Marketing Status Prescription
ATC Code N07XX06
DrugBank ID DB04844
KEGG ID D08575
MeSH ID D013747
PubChem ID 6018
TTD Drug ID D09PJX
NDC Product Code 0054-0469; 60505-3882; 51224-426; 43598-394; 27241-177; 42291-806; 51224-425; 65977-0085; 47335-277; 31722-822; 68180-408; 70436-102; 51407-481; 42291-807; 65085-0064; 65015-831; 0054-0468; 69452-117; 69766-076; 43598-395; 42973-179; 62756-871; 31722-821; 64330-066; 68180-409; 64567-0025; 68682-421; 63827-1013; 51407-480; 69452-118; 47335-179; 68682-422; 60505-3883; 70436-101; 27241-176
Synonyms Tetrabenazine | Nitoman | Xenazine
Chemical Information
Molecular Formula C19H27NO3
CAS Registry Number 718635-93-9
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Hypertension24.08.02.001--
Hypertonia17.05.02.001; 15.05.04.0070.002614%Not Available
Hypotension24.06.03.002--
Hypothermia12.05.03.001; 08.05.01.003--
Infection11.01.08.0020.002046%Not Available
Influenza22.07.02.001; 11.05.03.001--Not Available
Influenza like illness08.01.03.0100.002614%
Insomnia19.02.01.002; 17.15.03.0020.032679%
Intentional self-injury19.12.01.002; 12.01.08.036--Not Available
Irritability08.01.03.011; 19.04.02.0130.007843%
Laceration23.03.11.004; 12.01.06.0060.002614%Not Available
Lethargy17.02.04.003; 19.04.04.004; 08.01.01.0080.009150%
Leukopenia01.02.02.001--Not Available
Local swelling08.01.03.0130.002614%Not Available
Loss of consciousness17.02.04.004--Not Available
Malaise08.01.01.003--
Mastication disorder15.03.01.009; 07.01.06.016; 17.05.03.0060.003921%Not Available
Memory impairment19.20.01.003; 17.03.02.0030.006536%
Menstruation irregular21.01.01.005; 05.05.01.008--
Mental impairment19.21.02.003; 17.03.03.0020.002614%Not Available
Migraine24.03.05.003; 17.14.02.001--Not Available
Mood altered19.04.02.0070.002614%Not Available
Mood swings19.04.03.0010.003921%Not Available
Movement disorder17.01.02.0100.010457%Not Available
Muscle injury12.01.07.002; 15.05.07.001--Not Available
Muscle rigidity17.05.02.005; 15.05.04.0010.006536%Not Available
Muscle spasms15.05.03.0040.009150%
Muscle twitching15.05.03.0050.002614%Not Available
Muscular weakness17.05.03.005; 15.05.06.001--
Myocardial infarction24.04.04.009; 02.02.02.007--
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