Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tetrabenazine
Drug ID BADD_D02175
Description A drug formerly used as an antipsychotic but now used primarily in the symptomatic treatment of various hyperkinetic disorders. It is a monoamine depletor and used as symptomatic treatment of chorea associated with Huntington's disease. FDA approved on August 15, 2008.
Indications and Usage Treatment of hyperkinetic movement disorders like chorea in Huntington's disease, hemiballismus, senile chorea, Tourette syndrome and other tic disorders, and tardive dyskinesia
Marketing Status Prescription
ATC Code N07XX06
DrugBank ID DB04844
KEGG ID D08575
MeSH ID D013747
PubChem ID 6018
TTD Drug ID D09PJX
NDC Product Code 0054-0469; 60505-3882; 51224-426; 43598-394; 27241-177; 42291-806; 51224-425; 65977-0085; 47335-277; 31722-822; 68180-408; 70436-102; 51407-481; 42291-807; 65085-0064; 65015-831; 0054-0468; 69452-117; 69766-076; 43598-395; 42973-179; 62756-871; 31722-821; 64330-066; 68180-409; 64567-0025; 68682-421; 63827-1013; 51407-480; 69452-118; 47335-179; 68682-422; 60505-3883; 70436-101; 27241-176
Synonyms Tetrabenazine | Nitoman | Xenazine
Chemical Information
Molecular Formula C19H27NO3
CAS Registry Number 718635-93-9
SMILES CC(C)CC1CN2CCC3=CC(=C(C=C3C2CC1=O)OC)OC
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Cellulitis23.09.01.001; 11.02.01.0010.002614%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.007--
Chest pain22.02.08.003; 08.01.08.002; 02.02.02.011--Not Available
Choking22.02.05.0010.005229%Not Available
Chorea17.01.01.0010.009150%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.000682%Not Available
Coma17.02.09.0010.006536%Not Available
Completed suicide19.12.01.001; 08.04.01.010--Not Available
Confusional state19.13.01.001; 17.02.03.005--
Constipation07.02.02.001--
Coordination abnormal17.02.02.0040.002614%Not Available
Cough22.02.03.001--
Crying19.04.02.002; 17.02.05.013; 12.02.11.001; 08.01.03.0050.007843%Not Available
Death08.04.01.0010.112530%
Dehydration14.05.05.0010.014379%
Dementia19.20.02.001; 17.03.01.0010.002614%Not Available
Depressed level of consciousness17.02.04.0020.003921%
Depressed mood19.15.02.0010.006536%Not Available
Depression19.15.01.0010.065358%
Diabetes mellitus14.06.01.001; 05.06.01.0010.003921%Not Available
Diarrhoea07.02.01.001--
Disorientation17.02.05.015; 19.13.01.0020.002614%Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.005229%
Dizziness24.06.02.007; 17.02.05.003; 02.01.02.004--
Drooling17.02.05.0050.002614%Not Available
Dry mouth07.06.01.002--
Dysarthria19.19.03.001; 17.02.08.0010.006536%
Dyskinesia17.01.02.0060.022222%
Dysphagia07.01.06.0030.028758%
Dyspnoea22.02.01.004; 02.01.03.002--
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