Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Testosterone cypionate
Drug ID BADD_D02171
Description Testosterone cypionate is a synthetic derivative of testosterone in the form of an oil-soluble 17 (beta)-cyclopentylpropionate ester. Its benefit compared to other testosterone derivatives is the slow rate of release after injection and longer half-life. It was developed by the company Pharmacia and Upjohn and FDA approved on July 25, 1979.
Indications and Usage Testosterone cypionate is used in males that present conditions derived from a deficiency or absence of endogenous testosterone. These conditions are 1) primary hypogonadism, defined as the testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome or orchidectomy; and 2) hypogonadotropic hypogonadism characterized by idiopathic gonadotropin, LHRH deficiency or pituitary-hypothalamic injury from tumors, trauma or radiation.[L1153]
Marketing Status Prescription; Discontinued
ATC Code G03BA03
DrugBank ID DB13943
KEGG ID D00957
MeSH ID C016131
PubChem ID 441404
TTD Drug ID Not Available
NDC Product Code 62756-016; 0574-0820; 69097-536; 76420-065; 46439-8736; 48087-0096; 0409-6562; 71205-289; 51927-2706; 0009-0086; 0143-9659; 50090-0330; 51552-0104; 0009-0417; 0009-0347; 0143-9726; 0591-4128; 0409-6557; 72833-678; 60870-0252; 69097-802; 50090-4147; 62991-3132; 0517-1830; 64025-0021; 62756-017; 0143-9005; 52536-625; 51927-0189; 65089-0049; 50090-4920; 0009-0027; 63629-8705; 0574-0827; 50090-4921; 69097-537; 43647-678; 63187-647; 0009-0085; 50090-4446; 38779-0164; 63275-9982; 63629-8706; 82393-114; 46204-0371; 49803-006; 62756-015; 49452-7660; 0395-8137; 22552-0010
Synonyms testosterone 17 beta-cypionate | testosterone cypionate | testosterone 17 beta-cyclopentanepropionate | testosterone 17 beta-cyclopentylpropionate | Depo-Testosterone | Depo-Testosterone Cypionate | deposteron | Duratest | Testa-C | Testex Elmu | Andronate | Depostomead
Chemical Information
Molecular Formula C27H40O3
CAS Registry Number 58-20-8
SMILES CC12CCC3C(C1CCC2OC(=O)CCC4CCCC4)CCC5=CC(=O)CCC35C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood testosterone increased13.10.05.0020.004305%Not Available
Burning sensation17.02.06.001; 08.01.09.0290.003827%Not Available
Cardiac arrest02.03.04.0010.001497%
Cardiac failure02.05.01.0010.000499%
Cardiac failure congestive02.05.01.0020.009089%Not Available
Cardio-respiratory arrest02.03.04.002; 22.02.06.0070.000374%Not Available
Cardiogenic shock24.06.02.006; 02.05.01.0030.000374%Not Available
Cardiomyopathy02.04.01.0010.001913%Not Available
Cardiovascular disorder24.03.02.009; 02.01.01.0010.001997%Not Available
Cellulitis23.09.01.001; 11.02.01.0010.003348%Not Available
Cerebral infarction24.04.06.002; 17.08.01.0040.000957%Not Available
Cerebral thrombosis24.01.04.003; 17.08.01.0060.001435%Not Available
Cerebrovascular accident24.03.05.001; 17.08.01.0070.056446%
Chest discomfort08.01.08.019; 02.02.02.009; 22.02.08.0010.000957%Not Available
Chest pain08.01.08.002; 22.02.08.003; 02.02.02.0110.010524%Not Available
Chronic obstructive pulmonary disease22.03.01.0070.000957%Not Available
Confusional state19.13.01.001; 17.02.03.005--
Conjunctivitis11.01.06.012; 06.04.01.0020.002392%
Coordination abnormal17.02.02.0040.000957%Not Available
Coronary artery disease24.04.04.006; 02.02.01.0010.006219%Not Available
Coronary artery occlusion24.04.04.013; 02.02.01.0060.002392%Not Available
Coronary artery thrombosis02.02.01.007; 24.01.05.0020.000250%Not Available
Cough22.02.03.001--
Deafness04.02.01.0010.000957%Not Available
Death08.04.01.001--
Dementia19.20.02.001; 17.03.01.0010.000957%Not Available
Depression19.15.01.0010.008610%
Diplopia17.17.01.005; 06.02.06.0020.000957%Not Available
Disturbance in attention19.21.02.002; 17.03.03.0010.001435%
Dizziness17.02.05.003; 24.06.02.007; 02.01.02.0040.006219%
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