Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Testosterone
Drug ID BADD_D02170
Description Testosterone is a steroid sex hormone indicated to treat primary hypogonadism and hypogonadotropic hypogonadism.[L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone antagonizes the androgen receptor to induce gene expression that causes the growth and development of masculine sex organs and secondary sexual characteristics.[A187114,L8983,L8935,L8938,L8986,L8989,L8992,L8995] Testosterone was isolated from samples and also synthesized in 1935.[A186943]
Indications and Usage To be used as hormone replacement or substitution of diminished or absent endogenous testosterone. Use in males: For management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Use in females: For palliative treatment of androgen-responsive, advanced, inoperable, metastatis (skeletal) carcinoma of the breast in women who are 1-5 years postmenopausal; testosterone esters may be used in combination with estrogens in the management of moderate to severe vasomotor symptoms associated with menopause in women who do not respond to adequately to estrogen therapy alone.
Marketing Status Prescription; Discontinued
ATC Code G03BA03
DrugBank ID DB00624
KEGG ID D00075
MeSH ID D013739
PubChem ID 6013
TTD Drug ID D06XMU
NDC Product Code 48087-0113; 69238-1013; 49452-7652; 66887-004; 63629-2125; 0591-2114; 63629-2124; 0832-1120; 65089-0050; 63629-8455; 16714-967; 0603-7831; 0591-2363; 42667-5511; 49884-418; 82393-113; 24979-078; 76420-684; 43598-304; 38779-2598; 66887-001; 44132-008; 0832-1121; 64025-0010; 22552-0009; 0023-5990; 0051-8462; 38779-0163; 60870-0251; 45802-754; 70492-002; 51927-1026; 0591-2924; 71589-013; 0591-2921; 0591-2926; 51552-0029; 62332-488; 16714-968; 0245-0872; 44132-006; 0245-0871; 45802-366; 49452-7657; 0591-2925; 0051-8425; 76420-687; 68382-362; 76420-686; 0591-3216; 60592-721; 24979-130; 12875-8248; 45802-610; 76003-1083; 38779-2936; 0009-0074; 49884-510; 68180-943; 43647-568; 0051-8450; 0802-8068; 71589-011; 62991-2150; 69097-363; 0023-5992; 0009-5020; 0591-3524; 69339-158; 43742-1242; 76420-685; 70700-112; 68180-941; 63481-183; 43742-1436; 43742-0677; 63629-2352; 76420-699; 51552-0564; 16714-969; 0591-3217; 45802-281; 62332-552
Synonyms Testosterone | 17-beta-Hydroxy-4-Androsten-3-one | 17 beta Hydroxy 4 Androsten 3 one | Androtop | Histerone | Sterotate | Sustanon | Androderm | Testoderm | Testolin | Testopel | Testosterone Sulfate | AndroGel | 8-Isotestosterone | 8 Isotestosterone | 17-beta-Hydroxy-8 alpha-4-Androsten-3-one | 17 beta Hydroxy 8 alpha 4 Androsten 3 one | Andropatch | Testim
Chemical Information
Molecular Formula C19H28O2
CAS Registry Number 58-22-0
SMILES CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Blood testosterone free decreased13.10.05.0200.002672%Not Available
Cardiac ventricular thrombosis24.01.05.006; 02.01.01.0150.002078%Not Available
Coronary artery restenosis24.04.04.023; 12.02.01.024; 08.07.05.004; 02.02.01.0160.000594%Not Available
Urine alcohol test positive13.17.02.0150.000594%Not Available
Body height increased13.15.01.0360.000594%Not Available
Peripheral artery occlusion24.04.03.0220.002375%Not Available
Coronary bypass thrombosis24.01.05.008; 12.02.01.025; 02.02.01.0170.001188%Not Available
Blood alcohol increased13.17.02.0100.000594%Not Available
Heart injury12.01.11.003; 02.01.01.0100.002478%Not Available
Deformity08.01.03.0220.002078%Not Available
Thalamic infarction24.04.06.041; 17.08.01.0610.001188%Not Available
Carotid arteriosclerosis24.04.06.031; 17.08.02.0150.000594%Not Available
Quality of life decreased13.18.01.0130.006531%Not Available
Cerebellar ischaemia24.04.06.033; 17.08.01.0470.000891%Not Available
Basal ganglia infarction24.04.06.028; 17.08.01.0400.001188%Not Available
Sperm concentration zero13.20.01.0150.000594%Not Available
Basal ganglia stroke24.04.06.029; 17.08.01.0410.000594%Not Available
Vertebral artery dissection24.02.04.006; 17.08.06.0040.000594%Not Available
Spinal pain08.01.08.030; 17.10.01.020; 15.02.01.008--Not Available
Dermal absorption impaired23.03.03.064; 08.06.01.0300.000594%Not Available
Meniscus injury15.07.03.006; 12.04.03.0080.000594%Not Available
Invasive ductal breast carcinoma21.05.01.021; 16.10.01.0130.002078%Not Available
Penile contusion24.07.06.023; 23.03.11.020; 21.12.01.016; 12.01.15.0050.000594%Not Available
Ophthalmic vein thrombosis24.01.05.011; 06.07.02.0070.000594%Not Available
Disease susceptibility08.01.03.0660.002969%Not Available
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