Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Teriflunomide
Drug ID BADD_D02165
Description Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients using teriflunomide.
Indications and Usage Used in the treatment of relapsing forms of multiple sclerosis (MS).
Marketing Status Prescription
ATC Code L04AA31
DrugBank ID DB08880
KEGG ID D10172
MeSH ID C527525
PubChem ID 54684141
TTD Drug ID Not Available
NDC Product Code 69238-1303; 65727-058; 12579-186; 69238-1304; 66499-0059; 59285-001; 69539-032; 47621-049; 17337-0070; 69037-0016; 58468-0211; 63850-8081; 12579-185; 46708-888; 12579-191; 53747-061; 69539-033; 14501-0086; 58468-0210; 59651-036; 66039-916; 0115-1565; 12579-190
Synonyms teriflunomide | (Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide | (2Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide | 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide | 2-hydroxyethylidene-cyanoacetic acid-4-trifluoromethyl anilide | RS 61980 | Aubagio | HMR1726 | HMR-1726 | A 771726 | A 1726 | A771726 | A-771726 | A77 1726
Chemical Information
Molecular Formula C12H9F3N2O2
CAS Registry Number 163451-81-8
SMILES CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Haematemesis24.07.02.011; 07.12.02.002--Not Available
Haematochezia24.07.02.012; 07.12.02.0030.006948%Not Available
Haematocrit decreased13.01.05.0010.002316%Not Available
Haematoma24.07.01.001--
Haematuria24.07.01.047; 20.02.01.006--
Blood urine present13.13.02.002--Not Available
Haemoglobin decreased13.01.05.003--Not Available
Haemoptysis24.07.01.006; 22.02.03.004; 02.01.02.006--Not Available
Haemorrhagic stroke17.08.01.011; 24.07.04.014--Not Available
Hair texture abnormal23.02.06.0040.002316%
Hallucination19.10.02.002--
Hallucination, visual19.10.02.004--Not Available
Head discomfort17.02.05.0270.001737%Not Available
Headache17.14.01.0010.107113%
Heart rate increased13.14.04.0020.009264%Not Available
Hemiparesis17.01.04.0010.004053%
Hepatic cirrhosis09.01.04.001--Not Available
Hepatic failure09.01.03.002--
Hepatic function abnormal09.01.02.001--Not Available
Hepatic pain09.01.05.0050.002895%
Hepatic steatosis14.08.04.005; 09.01.07.0030.004053%Not Available
Hepatitis09.01.07.0040.007527%Not Available
Hepatitis A11.05.06.003; 09.01.09.0040.001737%Not Available
Hepatocellular injury09.01.07.0080.008685%Not Available
Hepatomegaly09.01.05.0010.002316%Not Available
Hepatotoxicity12.03.01.008; 09.01.07.009--Not Available
Hernia08.01.04.0010.001158%Not Available
Herpes simplex23.09.03.001; 11.05.02.0010.001158%Not Available
Herpes zoster23.09.03.002; 11.05.02.0030.016212%
Hiatus hernia22.09.02.004; 07.16.01.0010.001158%Not Available
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