Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Teriflunomide
Drug ID BADD_D02165
Description Teriflunomide is the active metabolite of leflunomide, and it acts as an immunomodulatory agent by inhibiting pyrimidine synthesis. It is marketed under the name Aubagio® and is indicated for the treatment of multiple sclerosis, specifically relapsing forms. The FDA label states an important warning about the risk of hepatoxicity and teratogenicity for patients using teriflunomide.
Indications and Usage Used in the treatment of relapsing forms of multiple sclerosis (MS).
Marketing Status Prescription
ATC Code L04AA31
DrugBank ID DB08880
KEGG ID D10172
MeSH ID C527525
PubChem ID 54684141
TTD Drug ID Not Available
NDC Product Code 69238-1303; 65727-058; 12579-186; 69238-1304; 66499-0059; 59285-001; 69539-032; 47621-049; 17337-0070; 69037-0016; 58468-0211; 63850-8081; 12579-185; 46708-888; 12579-191; 53747-061; 69539-033; 14501-0086; 58468-0210; 59651-036; 66039-916; 0115-1565; 12579-190
Synonyms teriflunomide | (Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide | (2Z)-2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide | 2-cyano-3-hydroxy-N-(4-(trifluoromethyl)phenyl)-2-butenamide | 2-hydroxyethylidene-cyanoacetic acid-4-trifluoromethyl anilide | RS 61980 | Aubagio | HMR1726 | HMR-1726 | A 771726 | A 1726 | A771726 | A-771726 | A77 1726
Chemical Information
Molecular Formula C12H9F3N2O2
CAS Registry Number 163451-81-8
SMILES CC(=C(C#N)C(=O)NC1=CC=C(C=C1)C(F)(F)F)O
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Emphysema22.01.02.0020.001158%Not Available
Encephalitis17.06.05.001; 11.01.03.0080.001737%
Enteritis07.08.03.0020.001737%
Eosinophil count decreased13.01.06.0030.001158%Not Available
Eosinophil count increased13.01.06.0040.002316%Not Available
Eosinophilia01.02.04.0010.003474%
Epididymitis11.01.19.005; 21.09.02.0010.001158%Not Available
Epilepsy17.12.03.002--Not Available
Epistaxis24.07.01.005; 22.04.03.001--
Epstein-Barr virus infection11.05.10.0040.001158%
Erysipelas11.02.06.001; 23.09.01.0020.002316%Not Available
Erythema23.03.06.0010.019686%Not Available
Erythema multiforme23.03.01.003; 10.01.03.0150.002316%
Erythema nodosum23.07.02.001; 10.02.01.0200.002316%Not Available
Extrasystoles02.03.02.0030.001158%Not Available
Eye disorder06.08.03.0010.002895%Not Available
Eye haemorrhage24.07.05.002; 06.07.02.0010.002316%Not Available
Eye inflammation06.04.05.0020.001737%Not Available
Eye irritation06.04.05.003--Not Available
Eye pain06.08.03.0020.004632%
Eye swelling06.08.03.0030.002895%Not Available
Facial pain08.01.08.0120.001158%
Facial paralysis17.04.03.008--Not Available
Faeces discoloured07.01.03.0020.004632%Not Available
Failure to thrive19.07.05.001; 18.04.01.003; 14.03.02.0080.000302%Not Available
Fatigue08.01.01.0020.102482%
Feeling abnormal08.01.09.0140.026055%Not Available
Feeling cold08.01.09.0080.004632%Not Available
Feeling hot08.01.09.0090.006948%Not Available
Feeling jittery08.01.09.016--Not Available
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