Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tenofovir disoproxil
Drug ID BADD_D02155
Description Tenofovir disoproxil fumarate (a prodrug of tenofovir), marketed by Gilead Sciences under the trade name _Viread_, belongs to a class of antiretroviral drugs known as nucleotide analogue reverse transcriptase inhibitors (nRTIs). This drug is prescribed in combination with other drugs for the management of HIV infection as well as for Hepatitis B therapy. Tenofovir disoproxil was initially approved in 2001 [FDA label].
Indications and Usage Tenofovir is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection in adults and pediatric patients 2 years of age and older. It is also indicated for the treatment of chronic hepatitis B in adults and pediatric patients 12 years of age and older.
Marketing Status Prescription
ATC Code J05AF07
DrugBank ID DB00300
KEGG ID D01982
MeSH ID D000068698
PubChem ID 5481350
TTD Drug ID D0D9HW
NDC Product Code 68554-0046
Synonyms Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine | 9-PMPA (tenofovir) | 9-(2-Phosphonomethoxypropyl)adenine | 9-(2-Phosphonylmethoxypropyl)adenine, (S)-isomer | 9-(2-Phosphonylmethoxypropyl)adenine, (+-)-isomer | Tenofovir Disoproxil Fumarate | Disoproxil Fumarate, Tenofovir | Fumarate, Tenofovir Disoproxil | Tenofovir Disoproxil | Disoproxil, Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098 | (R)-9-(2-phosphonylmethoxypropyl)adenine | Viread
Chemical Information
Molecular Formula C19H30N5O10P
CAS Registry Number 201341-05-1
SMILES CC(C)OC(=O)OCOP(=O)(COC(C)CN1C=NC2=C(N=CN=C21)N)OCOC(=O)OC(C)C
Chemical Structure
ADR Related Proteins Induced by Drug
ADR Term Protein Name UniProt AC TTD Target ID PMID
Not AvailableNot AvailableNot AvailableNot AvailableNot Available
ADRs Induced by Drug
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Renal disorder20.01.02.0020.137731%Not Available
Renal failure20.01.03.0050.137924%Not Available
Renal tubular acidosis20.05.03.003; 14.01.01.0050.044429%Not Available
Renal tubular disorder20.05.03.0040.235475%Not Available
Renal tubular necrosis20.01.07.0030.039986%Not Available
Respiratory distress22.02.01.0120.013329%Not Available
Respiratory failure22.02.06.002; 14.01.04.003--
Rhabdomyolysis15.05.05.002--
Rib fracture15.08.07.001; 12.04.07.0010.062201%Not Available
Sacroiliitis15.01.01.0120.008886%Not Available
Schizophrenia19.03.04.001--Not Available
Sciatica15.10.01.001; 17.10.03.0010.008886%Not Available
Seizure17.12.03.001--
Sepsis11.01.11.003--
Septic shock24.06.02.011; 11.01.11.004--Not Available
Sinusitis22.07.03.007; 11.01.13.005--
Skin disorder23.03.03.007--Not Available
Skin hyperpigmentation23.05.01.0030.008886%
Sleep disorder19.02.04.001--Not Available
Somnolence19.02.05.003; 17.02.04.006--
Speech disorder22.02.05.034; 19.19.02.002; 17.02.08.003--Not Available
Spinal compression fracture15.08.05.004; 14.04.04.003; 12.04.04.0010.031100%Not Available
Spinal fracture15.08.05.001; 12.04.04.0020.013329%
Spinal osteoarthritis15.01.04.0030.013329%Not Available
Splenomegaly01.09.02.0010.008886%Not Available
Squamous cell carcinoma16.16.01.0020.008886%Not Available
Stillbirth18.01.02.002; 08.04.01.0060.006954%Not Available
Stress fracture12.04.02.003; 15.08.02.0020.008886%Not Available
Suicidal ideation19.12.01.003--
Suicide attempt19.12.01.004--
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