Adverse Drug Reaction Classification System

Pharmaceutical Information
Drug Name Tenofovir
Drug ID BADD_D02154
Description Tenofovir is an acyclic nucleotide diester analog of adenosine monophosphate.[A37693] In the most strict sense and due to the fact that it presents a phosphate group bound to the nitrogenous base, it is determined as an actual nucleotide analog.[A37693] The antiviral activities of tenofovir were first reported in 1993 and this agent was commercially available since 2008 in the form of [tenofovir disoproxil] and [tenofovir alafenamide] in order to obtain oral bioavailability.[A18473, A178360]
Indications and Usage Tenofovir has been shown to be effective against HIV, herpes simplex virus-2, and hepatitis B virus.[A178330] To know more about the specific product indications, please visit the information in the orally available forms of tenofovir, [tenofovir alafenamide] and [tenofovir disoproxil].
Marketing Status experimental; investigational
ATC Code J05AF07
DrugBank ID DB14126
KEGG ID D06074
MeSH ID D000068698
PubChem ID 464205
TTD Drug ID D0D9HW
NDC Product Code Not Available
UNII 99YXE507IL
Synonyms Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine | 9-PMPA (tenofovir) | 9-(2-Phosphonomethoxypropyl)adenine | 9-(2-Phosphonylmethoxypropyl)adenine, (S)-isomer | 9-(2-Phosphonylmethoxypropyl)adenine, (+-)-isomer | Tenofovir Disoproxil Fumarate | Disoproxil Fumarate, Tenofovir | Fumarate, Tenofovir Disoproxil | Tenofovir Disoproxil | Disoproxil, Tenofovir | 9-(2-Phosphonylmethoxypropyl)adenine, (R)-isomer - T357098 | (R)-9-(2-phosphonylmethoxypropyl)adenine | Viread
Chemical Information
Molecular Formula C9H14N5O4P
CAS Registry Number 147127-20-6
SMILES CC(CN1C=NC2=C(N=CN=C21)N)OCP(=O)(O)O
Chemical Structure
ADRs Induced by Drug
*The priority for ADR severity classification is based on FAERS assessment, followed by the most severe level in CTCAE rating. If neither is available, it will be displayed as 'Not available'.
**The 'Not Available' level is hidden by default and can be restored by clicking on the legend twice..
ADR Term ADReCS ID ADR Frequency (FAERS) ADR Severity Grade (FAERS) ADR Severity Grade (CTCAE)
Nasopharyngitis22.07.03.002; 11.01.13.002--Not Available
Nausea07.01.07.001--
Neck pain15.03.04.009--
Neoplasm malignant16.16.01.0010.011632%Not Available
Nephrogenic diabetes insipidus20.05.03.010; 14.05.07.0020.003877%Not Available
Nephrolithiasis20.04.01.0020.009112%
Nephropathy20.05.03.0010.038969%Not Available
Nephropathy toxic20.05.03.002; 12.03.01.0100.058162%Not Available
Nephrotic syndrome20.05.01.0020.006786%
Nerve compression17.09.02.002; 12.01.12.0010.004265%Not Available
Nervous system disorder17.02.10.001--Not Available
Neuralgia17.02.07.0050.007561%
Neuropathy peripheral17.09.03.003--Not Available
Night sweats23.02.03.006; 08.01.03.0310.007561%Not Available
Oesophageal carcinoma16.13.06.001; 07.21.06.0010.003877%Not Available
Oesophageal stenosis07.13.02.0010.001939%
Optic neuritis17.04.05.001; 06.04.08.002; 10.02.01.0970.001939%Not Available
Osteoarthritis15.01.04.0010.011051%Not Available
Osteolysis15.02.03.008; 14.04.04.0060.001939%Not Available
Osteomalacia20.01.01.002; 15.02.03.001; 14.04.04.0010.011632%Not Available
Osteonecrosis15.02.04.007; 24.04.05.0040.159945%
Osteoporosis15.02.03.002; 14.04.04.0020.288871%
Osteoporotic fracture15.08.02.007; 14.04.04.007; 12.04.02.0050.006786%Not Available
Osteosclerosis15.02.04.0120.001939%Not Available
Pain08.01.08.0040.200077%
Pancreatitis07.18.01.001--
Paralysis17.01.04.0040.003877%Not Available
Pathological fracture16.32.03.007; 15.08.02.008; 12.04.02.0060.006786%Not Available
Peripheral coldness08.01.09.010; 23.06.04.008; 24.04.03.0060.006592%Not Available
Pharyngeal oedema23.04.01.016; 22.04.05.003; 10.01.05.0160.006592%Not Available
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ADReCS-Target
Drug Name ADR Term Target
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